etb — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25394	ETB067	ETB-067,ETB 067
	ETB067, an H-89 analog, acts as a PKA and AKT1 inhibitor with specificity on no longer inhibiting CAMK2B and neither affecting viability of mice nor causing any detectable tissue damage at the dose given.
T3474	RO 46-8443		Endothelin Receptor
	RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.		Endothelin Receptor
T2561	Macitentan	ACT-064992	Apoptosis , Endothelin Receptor
	Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).		Apoptosis , Endothelin Receptor
T73099	Etbicyphat	Trimethylopropane phosphate
	Etbicyphat (Trimethylopropane phosphate), a potent competitive antagonist of GABA(A) receptors, binds to GABA(A)-benzodiazepine receptors and induces epileptiform activities in hippocampal CA1 neurons.
T7817	Aprocitentan	ACT-132577	Endothelin Receptor
	Aprocitentan (ACT-132577) is ETA and ETB antagonist .		Endothelin Receptor
T10595	BQ-788	BQ788	Endothelin Receptor
	BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press...		Endothelin Receptor
TP2262L	IRL-1038 acetate	IRL-1038 acetate(144602-02-8 Free base)	Endothelin Receptor
	IRL-1038 acetate is a potent ETB endothelin receptor antagonist.		Endothelin Receptor
T15595L	IRL-1620 acetate	IRL-1620 acetate（142569-99-1 free base）	Endothelin Receptor
	IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.		Endothelin Receptor
T36008	Nebentan potassium
	Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned ...
T6258	Zibotentan	ZD4054	Apoptosis , Endothelin Receptor
	Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.		Apoptosis , Endothelin Receptor
T19309L1	Endothelin 1 (swine, human) acetate	Endothelin 1 (swine, human) acetate(117399-94-7 free base)	Endothelin Receptor
	Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor and acts through two types of receptors ETA and ETB.		Endothelin Receptor
T6265	Bosentan (hydrate)	Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203	Endothelin Receptor
	Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.		Endothelin Receptor
T22540L	Ac-Endothelin-1 (16-21), human acetate		Others
	Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i...		Others
T6264	Bosentan	Actelion,Ro 47-0203,Benzenesulfonamide	Endothelin Receptor
	Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th...		Endothelin Receptor
T5458	Darusentan	Lu-135252	Endothelin Receptor
	Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries		Endothelin Receptor
T0750	Sulfisoxazole	NU-445,Sulfafurazole	Endothelin Receptor , Antibacterial , Antibiotic , Autophagy
	Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ...
T17064	Tezosentan	RO 610612	Others
	Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).		Others
T15596	IRL 2500		Endothelin Receptor
	IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.		Endothelin Receptor
T10595L	BQ-788 sodium salt		Others
	BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).		Others
T12382	PD-159020		Others
	PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively).		Others