Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 528.00 | |
50 mg | In stock | $ 769.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 197.00 |
Description | IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor. |
Targets&IC50 | ETB:1.3 nM, ETA:94 nM |
In vivo | In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620[1]. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response[2]. |
Molecular Weight | 573.68 |
Formula | C36H35N3O4 |
CAS No. | 169545-27-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93.6 mg/mL (163.2 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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IRL 2500 169545-27-1 GPCR/G Protein Endothelin Receptor IRL-2500 IRL2500 inhibitor inhibit