eif4a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83935	eIF4A i28
	eIF4A i28, an inhibitor of the eukaryotic initiation factor-4A (eIF4A) with an IC50 of 8.60 μM in an eIF4A ATPase assay, effectively reduces the viability of BJAB Burkitt lymphoma cells, as indicated by an EC50 of 0.46 μ...
T39530	eIF4A3-IN-5	eIF4A3-IN-5
	eIF4A3-IN-5 is a highly effective inhibitor of eukaryotic initiation factor 4A (eIF4A), specifically targeting eIF4AI and eIF4AII. With its potent inhibitory properties, eIF4A3-IN-5 shows great potential for advancing re...
T62884	eIF4A3-IN-6
	eIF4A3-IN-6 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A) (e.g. eIF4AI and eIF4AII). eIF4A3-IN-6 has the potential to be investigated in eIF4A-dependent diseases, including cancer.
T62161	eIF4A3-IN-4
	eIF4A3-IN-4 is a novel inhibitor of eIF4A (IC50: 8.6 μM).
T72943	eIF4A3-IN-17
	eIF4A3-IN-17, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 0.9, 15, and 1.8 nM for myc-LUC, tub-LUC, and growth inhibition of MBA-MB-231 cells, respectively. Th...
T73001	eIF4A3-IN-9
	eIF4A3-IN-9, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 29, 450, and 80 nM for myc-LUC, tub-LUC, and growth inhibition in MBA-MB-231 cells, respectively. It i...
T11170	eIF4A3-IN-1		Others
	eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD...		Others
T11171	eIF4A3-IN-2		Others
	eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.		Others
T72746	(R)-eIF4A3-IN-2
	(R)-eIF4A3-IN-2, a less active enantiomer of eIF4A3-IN-2, is a highly selective and noncompetitive inhibitor of the eukaryotic initiation factor 4A-3 (eIF4A3) with an IC50 of 110 nM.
T39921	eIF4A3-IN-7	eIF4A3-IN-7
	eIF4A3-IN-7 is a highly effective inhibitor of eIF4A3, exhibiting significant potential for research in cancer and dysproliferative diseases.
T72944	eIF4A3-IN-18
	eIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively...
T22592	ATPγS tetralithium salt	ATP-gamma-S tetralithium salt	PERK
	ATPγS tetralithium salt is a substrate for nucleotide hydrolysis and RNA unraveling activity of the eukaryotic translation initiation factor eIF4A, associated with p97 mutants and prions.		PERK
T17296	Zotatifin	eFT226	Others
	Zotatifin is a potent and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM). Zotatifin effectively reduces viral infectivity by...		Others
T10847	CMLD012072		Others
	CMLD012072 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor with potent anti-neoplastic activity. It can induce RNA clamping of eIF4A1 and eIF4A2.		Others
T27544	Hippuristanol
	Hippuristanol is a potent steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).
T10848	CMLD012073		Others
	CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4...		Others
T38753	CR-1-31-B
	CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31...
T36750	Didesmethylrocaglamide
	Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects, with an IC50 of 5 nM. It hinders several growth-promoting si...
T10849	CMLD012612		Others
	CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).		Others
T71395	Rohinitib
	Rohinitib, a potent and specific eIF4A inhibitor, effectively induces apoptosis in acute myeloid leukemia (AML) cell lines and decreases the leukemia burden in AML xenograft models. This compound is utilized in the resea...

Compounds

eIF4A i28

T83935

Synonym: eIF4A3-IN-5

Synonym: eIF4A3-IN-7

ATPγS tetralithium salt

T22592

Synonym: ATP-gamma-S tetralithium salt

Didesmethylrocaglamide

Cat No.	Product Name	Synonyms	Targets
TQ0131	Rocaglamide	Rocaglamide A,Roc-A	HSP , NF-κB , PERK
	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
T11215	Episilvestrol		Others
	Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris.

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01306	EIF4A1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str...
TMPH-01307	EIF4A2 Protein, Human, Recombinant (GST)	Human	E. coli
	EIF4A2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.4 kDa and the accession number is Q14240.
TMPJ-00507	EIF4E Protein, Human, Recombinant	Human	E. coli
	Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and int...