cmk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10845	CMK		Others
	CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.		Others
T36347	Ac-YVAD-CMK	Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK	IL Receptor , Caspase , Immunology/Inflammation related , Pyroptosis
	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
T36819	Ac-FLTD-CMK		Caspase
	Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7...		Caspase
T76251L	Ac-FEID-CMK TFA		Pyroptosis
	Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur...		Pyroptosis
T39526	Decanoyl-RVKR-CMK TFA	DecRVKRcmk TFA,Decanoyl-RVKR-CMK TFA
	Decanoyl-RVKR-CMK (DecRVKRcmk) TFA effectively hinders the processing of over-expressed gp160 and suppresses HIV-1 replication.
T80745	Z-Ala-Ala-Asp-CMK	Z-AAD-CMK	Caspase
	Z-Ala-Ala-Asp-chloromethylketone (Z-AAD-CMK) is a selective inhibitor of granzyme B [1].		Caspase
TP2038	Decanoyl-RVKR-CMK
	Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion ...
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μ...
T73412	AAF-CMK
	AAF-CMK, a tripeptidylpeptidase II (TPPII) inhibitor, exhibits anti-tumor activity and induces apoptosis, making it applicable in leukemia research.
T80660	Z-DEVD-CMK
	Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].
T80553	MeOSuc-AAPA-CMK
	MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].
T82592	DEC-RVRK-CMK	Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
	Decanoyl-Arg-Val-Arg-Lys-chloromethylketone (DEC-RVRK-CMK) is a small, synthetic, irreversible cell-permeable competitive inhibitor of furin that exhibits strong antiviral activity against Zika virus (ZIKV) and Japanese ...
T72111	Ala-Ala-Pro-Val-chloromethylketone	AAPV-CMK
	Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.
T80659	Z-YVAD-CMK		Caspase
	Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].		Caspase
T76251	Ac-FEID-CMK
	Ac-FEID-CMK, a potent peptide inhibitor derived from zebrafish-specific GSDMEb, effectively reduces mortality and kidney injury during septic shock by inhibiting pyroptosis and mitigating acute kidney injury (AKI) in viv...
T81822	MeOSuc-AAPF-CMK	MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl
	MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) is a potent inhibitor of the enzyme proteinase K [1].
T80743	Z-APF-CMK
	Z-APF-CMK is a selective inhibitor of the calcium (Ca2+)-regulated nuclear scaffold protease (CRNSP), as reported in reference [1].
T78633	MeOSuc-AAPV-CMK	Elastase Inhibitor III
	MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated cleavage of adiponectin [1].
T80101	Z-GGF-CMK		Proteasome
	Z-GGF-CMK, a protease inhibitor, impedes ClpP1P2 and proteasome activity and demonstrates cytotoxic effects on HepG2 cells, with a CC50 value of 125 μM [1].		Proteasome
T72281	Caspase-9 Inhibitor III	Ac-LEHD-cmk
	Caspase-9 Inhibitor III (Ac-LEHD-cmk), a caspase-9 inhibitor, exhibits protective effects against ischemia-reperfusion-induced myocardial injury.