cbp-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79168	CBP-IN-1		Epigenetic Reader Domain
	CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM and 3100 nM, respectively [1].		Epigenetic Reader Domain
T7264	CBP/EP300-IN-1		Epigenetic Reader Domain
	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.		Epigenetic Reader Domain
T10717	Inobrodib	CBP-IN-1	Epigenetic Reader Domain
	Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.		Epigenetic Reader Domain
T12537	β-catenin/CBP-IN-1		Wnt/beta-catenin
	β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin		Wnt/beta-catenin
T15405	GNE-781		Epigenetic Reader Domain
	GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).		Epigenetic Reader Domain
T4247	I-CBP112 hydrochloride		Epigenetic Reader Domain
	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly re...		Epigenetic Reader Domain
TN1567	Delphinidin chloride		Estrogen Receptor/ERR , VEGFR
	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...		Estrogen Receptor/ERR , VEGFR
T39826	CBP/p300-IN-8	CBP/p300-IN-8
	CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity.
T15399	GNE-207		Epigenetic Reader Domain
	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expres...		Epigenetic Reader Domain
T62700	CBP/p300-IN-16
	CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).
T40143	PROTAC CBP/P300 Degrader-1	PROTAC CBP/P300 Degrader-1
	PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T79395	CBP/p300-IN-21		Epigenetic Reader Domain
	CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1].		Epigenetic Reader Domain
T15397	GNE-049		Epigenetic Reader Domain
	GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively).		Epigenetic Reader Domain
T40036	Thalidomide-NH-PEG4-COOH	Thalidomide-NH-PEG4-COOH
	Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300/CBP.
T79230	JET-209		PROTACs
	JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) values of 0.05 nM for CBP and 0.2 nM for p300. The compound comprise...		PROTACs
T74823	Bromodomain IN-2
	BD-IN-1, a pan bromodomain (BD) inhibitor, exhibits K_D values of 250 nM for BRD4(1), 420 nM for CBP, 130 nM for BRPF1B, 430 nM for BRD7, 67 nM for BRD9, 240 nM for BRDT(1), and 970 nM for CECR2, respectively. This compo...
T81314	Rademikibart	CBP-201
	Rademikibart (CBP-201) is a human monoclonal antibody selective for IL-4Rα, exhibiting strong affinity with a KD of 20.7 pM for human IL-4Rα epitopes, without cross-reactivity to IL-4Rα from other species. It effectively...
T69014	Sekikaic Acid
	Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µ...