cb-1-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5996	CB1-IN-1	DBPR211	Cannabinoid Receptor
	CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.		Cannabinoid Receptor
T10697	CB2R-IN-1		Others
	CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).		Others
T30252	AZD1940	UNII-0J0035E9FT,AZD-1940,AZD 1940	Cannabinoid Receptor
	AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.		Cannabinoid Receptor
T5S1897	Linderalactone		Apoptosis , Others , JAK
	1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.		Apoptosis , Others , JAK
T8425	Linoleoyl Ethanolamide		TRP/TRPV Channel
	Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.		TRP/TRPV Channel
T4654	(±)-Ibipinabant	(±)-BMS6462,SLV319,(±)-SLV319	Cannabinoid Receptor
	(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.		Cannabinoid Receptor
T36520	COR659		Cannabinoid Receptor , GABA Receptor
	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...		Cannabinoid Receptor , GABA Receptor
T23099	O-2050		Others
	O-2050 is a high affinity cannabinoid CB 1 receptor antagonist with a K i of 2.5 nM. O-2050 inhibits cannabinoid CB 2 receptor with Ki of 0.2 nM. O-2050 decreased food intake in mice and caused locomotor stimulation in m...		Others
T78083	CB-25		Cannabinoid Receptor
	CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells [1].		Cannabinoid Receptor
T61336	Numidargistat dihydrochloride
	Numidargistat dihydrochloride (CB-1158) is a highly potent and orally active chemical compound that effectively inhibits arginase. It exhibits IC50 values of 86 nM and 296 nM for recombinant human arginase 1 and 2, respe...
T28235	OMDM169	OMDM 169,OMDM-169
	OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM1 microM tow...
T39309	Telaglenastat hydrochloride	CB-839 hydrochloride
	Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) a...
T38028	(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide
	N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Docosahexaenoyl ethanolamide (DHEA) has potential signaling roles in cancer, inflammation, and neurolog...
T38138	ACEA	2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces ...
T38204	GAT229
	GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB ago...