c5a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T80131	C5a Anaphylatoxin (human)		Complement System
	C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses, including allergic asthma [1] [2].		Complement System
T80265	C5a Receptor agonist, mouse, human		Complement System
	C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonist for the C5a receptor. This peptide plays a role in mediat...		Complement System
T9915	Eculizumab		Complement System
	Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5		Complement System
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System
T82797	C5aR1 antagonist peptide
	C5aR1 antagonist peptide, a biologically active linear peptide originating from the C-terminus of the chemokine complement fragment 5 anaphylatoxin (C5a), inhibits C5a binding and activity at human and rat C5a receptors....
T73262	C5aR-IN-3
	C5aR-IN-3, a potent C5aR inhibitor, holds potential for inflammation disease research due to its ability to counteract increased C5a levels, which are linked to autoimmune and inflammatory disorders.
T73261	C5aR-IN-1
	C5aR-IN-1, a potent inhibitor of C5aR, is linked with the potential to research inflammatory diseases. This association is due to the elevated levels of C5a, which are connected with autoimmune and inflammatory disorders...
T64200	C5aR-IN-2
	C5aR-IN-2 is a potent inhibitor of C5aR. C5aR-IN-2 has shown potential for the study of inflammatory diseases.
TP1834	MUC5AC motif peptide
	MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
T60161	CP-289		Complement System
	CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.		Complement System
T60151	CP-447697		Complement System
	CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.		Complement System
T12506L1	PMX 205 acetate(514814-49-4 free base)		Complement System
	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).		Complement System
T8223	Avacopan	CCX168	Complement System
	Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model o...		Complement System
TP2334	PMX 53 acetate(219639-75-5 free base)		Complement System
	PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an ag...		Complement System
T9316	JR14a	5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride	Complement System
	JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.		Complement System
T12506L	PMX 205		Others
	PMX 205 is an effective complement antagonist of the C5a receptor.		Others
T73710	PMX 205 Trifluoroacetate
	PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.
T76913	Avdoralimab
	Avdoralimab (IPH 5401), a fully human IgGκ monoclonal antibody, specifically inhibits the complement C5a receptor 1 (C5aR1) by preventing its interaction with C5a. This compound is utilized in research concerning complem...
T12506	PMX 205 Trifluoroacetate (514814-49-4 free base)	PMX 205 Trifluoroacetate	Others
	PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.		Others
T28429	PMX-53	PMX53,PMX 53
	PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-...