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PMX 205 acetate(514814-49-4 free base)

Catalog No. T12506L1 CAS T12506L1

PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).

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PMX 205 acetate(514814-49-4 free base) Chemical Structure

PMX 205 acetate(514814-49-4 free base), CAS T12506L1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 113.00
5 mg	In stock	$ 296.00
10 mg	In stock	$ 389.00
25 mg	In stock	$ 827.00
50 mg	In stock	$ 1,320.00
100 mg	In stock	$ 1,928.00
1 mL * 10 mM (in DMSO)	In stock	$ 415.00

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Purity: 99.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
In vitro	PMX 205 (PMX205) group is in between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748 and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. For the 48 h plate of incubation time, only two groups of PMX 205 and Tamoxifen show a significant result. The values recorded are in between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively. For the 72 h plate, only one group shows a significant result, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322[1].
In vivo	Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. In 3×Tg mice, PMX 205 also significantly reduces hyperphosphorylated tau (69%)[2].

Molecular Weight	899.09
Formula	C47H66N10O8
CAS No.	T12506L1

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (66.73 mM)

References and Literature

1. Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6. 2. Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library

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Keywords

PMX 205 acetate(514814-49-4 free base) T12506L1 Immunology/Inflammation Complement System PMX 205 acetate(514814494 free base) PMX 205 acetate(514814 49 4 free base) inhibitor inhibit

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