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PMX 205

Catalog No. T12506L CAS 514814-49-4

PMX 205 is an effective complement antagonist of the C5a receptor.

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PMX 205, CAS 514814-49-4

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1 mg	35 days	$ 928.00

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Biological Description

Chemical Properties

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Description	PMX 205 is an effective complement antagonist of the C5a receptor.
In vitro	In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with negative control group. For the PMX 205 group, the value recorded is between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748, and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. Only one group shows a significant result for the 72 h plate, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322. Only two groups show a significant result for the 48 h plate of incubation time, which are PMX 205 and Tamoxifen. The values recorded are between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively [1].
In vivo	PMX 205 (1 mg/kg/day; SOD1G93A rats; p.o.) from two-time points (days 28 and 70) before the onset of major clinical symptoms. Both treatment groups have a significant extension in survival time compared with untreated rats (p=0.022, day 28; p=0.015, day 70), with no clear differences in outcomes between the two treatment regimens. PMX 205-treated animals also display reduced levels of astroglial proliferation in the lumbar spinal cord. Animals treated with PMX 205 (1 mg/kg/day, oral) show a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. PMX 205 also significantly reduces hyperphosphorylated tau (69%) in 3×Tg mice [2][3].

Molecular Weight	839.04
Formula	C45H62N10O6
CAS No.	514814-49-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6. 2. Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34. 3. Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83.

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Keywords

PMX 205 514814-49-4 Others PMX205 PMX-205 inhibitor inhibit

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