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PMX 205 Trifluoroacetate (514814-49-4 free base)

Catalog No. T12506 CAS T12506

Synonyms: PMX 205 Trifluoroacetate

PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.

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PMX 205 Trifluoroacetate (514814-49-4 free base) Chemical Structure

PMX 205 Trifluoroacetate (514814-49-4 free base), CAS T12506

Pack Size	Availability	Price/USD	Quantity
1 mg	Inquiry	$ 113.00
5 mg	Inquiry	$ 296.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
In vitro	PMX205, which is an antagonist, gave more effects towards the cell as compared with the treatment of EP54.
In vivo	oral delivery of a cyclic hexapeptide C5a receptor antagonist (PMX205) for 2-3 mo resulted in substantial reduction of pathological markers such as fibrillar amyloid deposits (49-62%) and activated glia (42-68%) in two mouse models of AD. The reduction in pathology was correlated with improvements in a passive avoidance behavioral task in Tg2576 mice. In 3xTg mice, PMX205 also significantly reduced hyperphosphorylated tau (69%). These data provide the first evidence that inhibition of a proinflammatory receptor-mediated function of the complement cascade (i.e., C5aR) can interfere with neuroinflammation and neurodegeneration in AD rodent models, suggesting a novel therapeutic target for reducing pathology and improving cognitive function in human AD patients[3].

Synonyms	PMX 205 Trifluoroacetate
Molecular Weight	953.06
Formula	C47H63F3N10O8
CAS No.	T12506

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (104.93 mM)

H2O: 0.67 mg/mL (0.70 mM), Sonication is recommended.

References and Literature

1. Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6. 2. Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34. 3. Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PMX 205 Trifluoroacetate (514814-49-4 free base) T12506 Others 514814-49-4 PMX205 Trifluoroacetate PMX 205 Trifluoroacetate (514814 49 4 free base) PMX 205 Trifluoroacetate (514814494 free base) PMX-205 Trifluoroacetate PMX 205 Trifluoroacetate 514814-49-4 free base inhibitor inhibit

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