bcr-abl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72958	BCR-ABL-IN-7		Bcr-Abl
	BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.		Bcr-Abl
T39732	BCR-ABL-IN-3
	BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer acti...
T10489	BCR-ABL-IN-2		Others
	BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).		Others
T10488	BCR-ABL-IN-1		Bcr-Abl
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.		Bcr-Abl
T5177	Asciminib	ABL001	Bcr-Abl
	Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).		Bcr-Abl
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T3071	Olverembatinib	GZD 824	Bcr-Abl
	Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).		Bcr-Abl
T8488	GMB-475		Bcr-Abl
	GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...		Bcr-Abl
T8882	Vodobatinib	K-0706	Bcr-Abl
	Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.		Bcr-Abl
T17267	XL228		IGF-1R , Bcr-Abl , Src , Aurora Kinase
	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).		IGF-1R , Bcr-Abl , Src , Aurora Kinase
T2429	Olverembatinib dimesylate	GZD824 Dimesylate,HQP1351	Bcr-Abl
	Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).		Bcr-Abl
T0152	Bosutinib	SKI-606	Bcr-Abl , Src , Autophagy
	Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.		Bcr-Abl , Src , Autophagy
T3063	PD173955	PD-173955,PD 173955	Apoptosis , Bcr-Abl , Src
	PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC.		Apoptosis , Bcr-Abl , Src
T6300	Degrasyn	WP1130	Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
	Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri...		Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
T1803	GNF-5	GNF 5	SARS-CoV , Bcr-Abl
	GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.		SARS-CoV , Bcr-Abl
T11916	Lyn-IN-1	Bafetinib analog	Bcr-Abl , Src
	Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn		Bcr-Abl , Src
T63332	BCR-ABL-IN-5
	BCR-ABL-IN-5 is a Bcr-Abl (Breakpoint cluster region-Abelson) kinase inhibitor that acts on Bcr-AblWT (IC50: 0.014 μM) and Bcr-AblT3151 (IC50: 0.45 μM) and exhibits some anti-proliferative effects on leukemic cells. effe...
T82909	BCR-ABL-IN-8		Bcr-Abl
	BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].		Bcr-Abl
T63450	BCR-ABL-IN-6
	BCR-ABL-IN-6 (9h) is an imatinib derivative and a selective inhibitor of Bcr-Abl kinase that acts on Bcr-AblWT (IC50: 4.6 nM) and Bcr-AblT3151 (IC50: 277 nM). BCR-ABL-IN-6 (9h) was able to be used in the study of chronic...
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...