ak1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T12885	SGC-AAK1-1		AAK1 (AP2 associated kinase 1)
	SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.		AAK1 (AP2 associated kinase 1)
T77504	JAK1/2/3 Inhibitor 1		PKA
	JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the c...		PKA
T40577	TAK1-IN-3		MAPK
	TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.		MAPK
T35899	JAK1-IN-8	JAK1-IN-8	JAK
	JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).		JAK
T16367	NVS-PAK1-1		PAK
	NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).		PAK
T63834	AAK1-IN-3 TFA
	AAK1-IN-3 TFA is an adaptor protein 2-associated kinase 1 (AAK1) inhibitor (IC50: 11 nM) that crosses the blood-brain barrier and is a quinoline analogue.AAK1-IN-3 has shown potential for research in neuropathic pain.
T64265	JAK1/TYK2-IN-3
	JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 ...
T70877	JAK1-IN-B61
	JAK1-IN-B61 is a JAK1 inhibitor.
T41166	NVS PAK1 C
	NVS PAK1 C is a negative control of NVS PAK1 1, a potent and selective PAK1 inhibitor.
T82513	EAK16-II
	EAK16-II, an amphipathic peptide, concentration-dependently inhibits the self-sorting of EAKIIH6 [1].
T34630	SGC-AAK1-1N	SGCAAK11N,SGCAAK1-1N,SGC-AAK11N
	SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1].
T72957	DRAK1/2-IN-1
	DRAK1/2-IN-1 is a potent inhibitor targeting both DRAK1 and DRAK2, displaying dissociation constants (Kd) of 1 µM and 6 µM, respectively.
T60828	AAK1-IN-2
	AAK1-IN-2 (compound (S)-31) can be used in neuropathic pain research that is a potent, selective and brain-penetrant Adaptor Protein 2-Associated Kinase 1(AAK1) inhibitor (IC 50 = 5.8 nM) [1].
T72421	LRRK2/NUAK1/TYK2-IN-1
	LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
T63031	PAK1-IN-1
	PAK1-IN-1 is a selective and potent inhibitor of PAK1 (IC50: 9.8 nM). PAK1-IN-1 inhibits PAK1-associated tumour cell migration and invasion in a dose-dependent manner.
T63833	AAK1-IN-2 TFA
	AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.
T67909	TAK1 inhibitor	compound 13a	Topoisomerase
	TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor showed good antibacterial activity with microphones ranging fro...		Topoisomerase
T61693	AAK1-IN-5
	AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivit...
T10444	TAK1/MAP4K2 inhibitor 1		Others
	TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFβ-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1 nM and 18.2 nM).		Others