Search Result

Search Results for " aaa "

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-...
T40048	MC-AAA-NHCH2OCH2COOH	MC-AAA-NHCH2OCH2COOH
	MC-AAA-NHCH2OCH2COOH (compound 20) is a cleavable antibody-drug conjugate (ADC) linker. Its primary application lies in the synthesis of ADCs.
T40049	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a mono...
T63060	AAA-10
	AAA-10 is an orally active inhibitor of bile salt hydrolase (BSH) in B. intestinalis that acts on B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).
T63616	AAA-10 formic
	AAA-10 formic is an orally active inhibitor of intestinal bacterial bile salt hydrolase (BSH) against B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).
T8513	Spastazoline		Others
	Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).		Others
T9882	RUVBL1/2 ATPase-IN-1		Others
	RUVBL1/2 ATPase-IN-1 is an effective RUVBL1/2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1/2 ATPase-IN-1 can be used in cancer disease studies.		Others
T6796	CB-5083	CB5083,CB 5083	p97
	CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).		p97
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT is a double-stranded ribonucleoside that is modified with the fluorescent molecule 5'6-FAM, a combination of 5-FAM and 6-FAM. The excitation/emission wavelengths of 5-F...
T60432	NAAA-IN-3
	NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola...
T60378	NAAA-IN-2
	NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OE...
T60767	NAAA-IN-1
	NAAA-IN-1 (Compound 1) can be used in the inflammation and pain research. NAAA-IN-1 is a potent and selective NAAA inhibitor (IC 50 = 7 nM). NAAA is a cysteine amidase. NAAA preferentially hydrolyzes the endogenous bioli...
T5425	ML367		Epigenetic Reader Domain
	ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitory activity		Epigenetic Reader Domain
T28506	Rbin-2		Phosphatase
	Rbin-2 is a cell-permeable, potent, selective and reversible inhibitor of Midasin (Mdn1).Rbin-2 directly targets the AAA+ ATPase Midasin and inhibits eukaryotic ribosome production, making it a potent probe for the study...		Phosphatase
T14965	Ciliobrevin D		ATPase , Hedgehog/Smoothened
	Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ...		ATPase , Hedgehog/Smoothened
T72043	SCFSkp2-IN-2		Apoptosis , E1/E2/E3 Enzyme
	SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.		Apoptosis , E1/E2/E3 Enzyme
T9008	NPD8733		Others
	NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.		Others
T29068	UPCDC-30245	UPCDC 30245
	UPCDC30245 is an AAA ATPase p97 allosteric inhibitor.
T39008	PRMT5-IN-4	PRMT5-IN-4
	PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.
T12114	MSC1094308		p97
	MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.		p97
T77820	7-Aminomethyl-10-methyl-11-fluoro camptothecin
	7-Aminomethyl-10-methyl-11-fluoro camptothecin, serving as a cytotoxic component of the antibody-drug conjugate (ADC) MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, is employed in the synthesis of ca...
T74446	OF-02
	OF-02, an alkenyl amino alcohol (AAA) ionizable lipid, demonstrates high potency for in vivo mRNA delivery.
T27165	Diazaborine	Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
	Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of ...

Compounds

MC-AAA-NHCH2OCH2COOH

T40048

Synonym: MC-AAA-NHCH2OCH2COOH

Target:

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

T40049

Synonym: MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Synonym: CB5083,CB 5083

Target: p97

5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT

Target: Epigenetic Reader Domain

Target: ATPase, Hedgehog/Smoothened

SCFSkp2-IN-2

T72043

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

7-Aminomethyl-10-methyl-11-fluoro camptothecin

Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03263	RUVBL1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It poss...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc)	Human	HEK293
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03884	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03885	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02110	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02221	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPH-03181	LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO)	Pseudomonas azotoformans	E. coli
	Hydrolyzes L-prolinamide, L-proline-p-nitroanilide, L-alaninamide, L-methioninamide, piperidine-2-carboxamide and piperazine-2-carboxamide. Has a much lower activity towards piperazine-2-tert-butylcarboxamide. Does not h...
TMPJ-01013	VCP Protein, Human, Recombinant (His)	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi...