a2a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37792	A2A receptor antagonist 1	CPI-444 analog,A2A receptor antagonist 1	Adenosine Receptor
	A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.		Adenosine Receptor
T62797	A2A receptor antagonist 3
	A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist (Ki: 0.4 nM). receptor (Ki: 1467 nM).
T63326	A2A receptor antagonist 2
	A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).
T60732	A2A/A1 AR antagonist-1
	A2A/A1 AR antagonist-1 (compound 1a) has the potential for ischemic stroke research which is potent A 2A /A 1 AR dual antagonist with Ki s of 5.58 and 24.2 nM, respectively [1].
T74606	A2A/A3 AR antagonist-1
	Compound 23, designated as A2A/A3 AR antagonist-1, is a dual fluorescent ligand targeting A2A and A3 adenosine receptors (AR), exhibiting dissociation constants (Ki) of 90 nM for hA2A AR and 31.8 nM for hA3 AR, respectiv...
T16378	Ogerin		Others , 5-HT Receptor , Adenosine Receptor
	Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak an...		Others , 5-HT Receptor , Adenosine Receptor
T23336	SCH442416	SCH 442416	Adenosine Receptor
	SCH442416 (SCH 442416) is an selective antagonist of adenosine A2A receptor. SCH442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).		Adenosine Receptor
T10212	A2AR-agonist-1	N-(2-(1H-Indol-3-yl)ethyl)adenosine	Others , Adenosine Receptor
	A2AR-agonist-1 (N-(2-(1H-Indol-3-yl)ethyl)adenosine) is a potent A2AR and ENT1 agonist (Ki: 4.39 and 3.47 for A2AR and ENT1. It targets the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.		Others , Adenosine Receptor
T16873	SERCA2a activator 1		Calcium Channel
	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.		Calcium Channel
T60591	A2AAR antagonist 1
	A2AAR antagonist 1 (compound 21a) is an antagonist of A2AAR (adenosine A2A receptor) that shows high ligand efficiency with a Ki value of 20 nM. A2AAR antagonist 1 can be used in neurodegenerative disease research [1].
T72626	A2AR-antagonist-1		Adenosine Receptor
	A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally,...		Adenosine Receptor
T62717	A2AAR/HDAC-IN-2
	A2AAR/HDAC-IN-2 is a potent dual A2AAR/HDAC inhibitor.A2AAR/HDAC-IN-2 shows good affinity for A2AAR (Ki:10.3 nM) and inhibits HDAC1 well (IC50:18.5 nM). A2AAR/HDAC-IN-2 can be used in anti-tumour studies.
T63400	HA2A/hCA XII modulator 1
	hA2A/hCA XII modulator 1 is a potent antagonist of the hA2A adenosine receptor (hA2AAR), a triazolopyrazine that acts on hA2AAR (Ki: 6.4 nM), hA1AR (Ki: 4.819 μM), and hA3AR (Ki>30 μM). hA2A/hCA XII modulator 1 Also a po...
T62521	A2AAR/HDAC-IN-1
	A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.
T6979	SCH 58261	SCH58261	Adenosine Receptor
	SCH 58261 is a potent and selective A2a adenosine receptor antagonist.The Ki =2.3 nM for rat A2a and 2 nM is for bovine A2a.		Adenosine Receptor
T7320	Tozadenant	SYN115	Adenosine Receptor
	Tozadenant (SYN115) is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)		Adenosine Receptor
T4290	Preladenant	SCH-420814	Adenosine Receptor
	Preladenant (SCH-420814) is an orally bioavailable antagonist of the adenosine A2A receptor (Ki: 1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.		Adenosine Receptor
T9516	Binodenoson	WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos	Adenosine Receptor
	Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres...		Adenosine Receptor
T2373	Vipadenant	CEB-4520,BIIB-014	Adenosine Receptor
	Vipadenant (CEB-4520)(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).		Adenosine Receptor
T34685	Sonedenoson	MRE-0094,MRE0094,MRE 0094
	Sonedenoson( MRE0094) is an adenosine A2A receptor agonist that promotes rapid wound healing.