keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 139.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 447.00 | |
25 mg | In stock | $ 739.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 327.00 |
Description | Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1]. |
Targets&IC50 | A2A:270 nM(kd) |
In vitro | 2-(cyclohexylmethylidenehydrazino)adenos (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1]. |
In vivo | The compound 2-(cyclohexylmethylidenehydrazino)adenos, administered at dosages ranging from 0-0.9 μg/kg/h to adult Wistar rats in a bacterial meningitis model, either alone or combined with rolipram (0-0.01 μg/kg/h), effectively suppresses pleocytosis and mitigates the lipopolysaccharide-induced elevation in blood-brain barrier permeability (BBBP). This suggests a reduction in neutrophil-induced damage[1]. |
Synonyms | WRC 0470, MRE-0470, 2-(cyclohexylmethylidenehydrazino)adenos |
Molecular Weight | 391.42 |
Formula | C17H25N7O4 |
CAS No. | 144348-08-3 |
keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (28.1 mM)
You can also refer to dose conversion for different animals. More
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Binodenoson 144348-08-3 GPCR/G Protein Neuroscience Adenosine Receptor imaging P1 receptor WRC-0470 WRC 0470 stress oxidative neutrophil MRE-0470 WRC0470 inhibit radiotracers Inhibitor 2-(cyclohexylmethylidenehydrazino)adenos MRE0470 myocardial MRE 0470 inhibitor