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Synonyms: Ubiquitin-Protein Ligase, Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2(25K), Ubiquitin-Conjugating Enzyme E2 K, Ubiquitin Carrier Protein, UBE2K, Huntingtin-Interacting Protein 2, HIP-2, HIP2

| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $35 | 35 days | 35 days | |
| 20 µg | $51 | 35 days | 35 days | |
| 50 µg | $91 | 35 days | 35 days | |
| 100 µg | $168 | 35 days | 35 days | |
| 200 µg | $325 | 35 days | 35 days | |
| 500 µg | $781 | 35 days | 35 days | |
| 1 mg | $1,120 | 35 days | 35 days |
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-GST |
| Accession Number | P61086 |
| Amino Acid | Met1-Asn200 |
| Construction | Met1-Asn200 |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 2 mM DTT, 10% Glycerol, pH 7.5. |
| Synonyms | Ubiquitin-Protein Ligase, Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2(25K), Ubiquitin-Conjugating Enzyme E2 K, Ubiquitin Carrier Protein, UBE2K, Huntingtin-Interacting Protein 2, HIP-2, HIP2 |
| Research Background | Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins. |
| Molecular Weight | 45 KDa (reducing condition) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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