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[6]-Gingerol

Catalog No. T3405 CAS 23513-14-6

Synonyms: 6-Gingerol, gingerol, (S)-(+)-[6]Gingerol

[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.

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[6]-Gingerol, CAS 23513-14-6

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 120.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.59%

Purity: 99.31%

Purity: 99.25%

Purity: 98%

Biological Description

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Storage & Solubility Information

Description	[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
In vitro	[6]-Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activation[1]. Moreover, [6]-gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMPK[2]. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein levels[3].
In vivo	In animal studies, [6]-gingerol effectively mitigates DSS-induced colitis symptoms, including reversing body weight loss, decreasing intestinal bleeding, and preventing shortening of the colon. Additionally, [6]-gingerol inhibits the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2].
Cell Research	[6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1].
Source	Natural Products > Zingiberaceae > Zingiber

Synonyms	6-Gingerol, gingerol, (S)-(+)-[6]Gingerol
Molecular Weight	294.39
Formula	C17H26O4
CAS No.	23513-14-6

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 53 mg/mL(180 mM)

References and Literature

1. Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9(8):e104401. 2. Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6(10):3334-41. 3. Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36(2):1135-41.

Citations

1. Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021：1781 2. Kamaruddin M S H, Chong G H, Umanan F, et al.Enhancement of 6-gingerol extraction from Bentong ginger using supercritical carbon dioxide.Journal of CO2 Utilization.2023, 72: 102505.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Kinase Inhibitor Library Marine Natural Product Library Anti-Cancer Metabolism Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Glycolysis Compound Library RO5 Drug-like Natural Product Library Apoptosis Compound Library Natural Product Library

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Keywords

[6]-Gingerol 23513-14-6 Apoptosis Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK 6-Gingerol AMP-activated protein kinase inhibit [6] Gingerol gingerol [6]Gingerol (S)-(+)-[6]Gingerol Inhibitor inhibitor

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