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Catalog No. T35317   CAS 110703-94-1
Synonyms: CP-73850, Zopolrestatum, CP73850, CP 73850

Zopolrestat is a potent inhibitor of aldose <a href="/target/Reductase" style="display: inline; color: #c13a36">Reductase</a> (IC50 = 3.1 nM).

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Zopolrestat, CAS 110703-94-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 54.00
5 mg In stock $ 77.00
10 mg In stock $ 122.00
25 mg In stock $ 239.00
50 mg In stock $ 383.00
100 mg In stock $ 597.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Targets&IC50 Aldose reductase:3.1 nM
In vitro Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1].
In vivo After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1].
Synonyms CP-73850, Zopolrestatum, CP73850, CP 73850
Molecular Weight 419.38
Formula C19H12F3N3O3S
CAS No. 110703-94-1


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 11 mg/mL (26.23 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mylari BL, et al. Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. J Med Chem. 1991;34(1):108-122. 2. Zhai J, et al. Zopolrestat as a human glyoxalase I inhibitor and its structural basis. ChemMedChem. 2013 Sep;8(9):1462-4. 3. Badawy D, et al. Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity. Can J Physiol Pharmacol. 2013 Feb;91(2):101-7. 4. Ramasamy R, et al. Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat. Cardiovasc Res. 1999 Apr;42(1):130-9.

Related compound libraries

This product is contained In the following compound libraries:
Orally Active Compound Library Bioactive Compound Library Human Metabolite Library Inhibitor Library Metabolism Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library

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Zopolrestat 110703-94-1 Endocrinology/Hormones Metabolism Reductase CP-73850 diabetic potent glyceraldehyde Zopolrestatum glucose aldose CP73850 rats inhibit Aldose Reductase Inhibitor CP 73850 oral inhibitor