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Zopolrestat

🥰Excellent
Catalog No. T35317Cas No. 110703-94-1
Alias Zopolrestatum, CP-73850, CP73850, CP 73850

Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

Zopolrestat

Zopolrestat

🥰Excellent
Purity: 99.74%
Catalog No. T35317Alias Zopolrestatum, CP-73850, CP73850, CP 73850Cas No. 110703-94-1
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
2 mg$40In StockIn Stock
5 mg$61In StockIn Stock
10 mg$93In StockIn Stock
25 mg$198In StockIn Stock
50 mg$313In StockIn Stock
1 mL x 10 mM (in DMSO)$77In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.74%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Targets&IC50
Aldose reductase:3.1 nM
In vitro
Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1].
In vivo
After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1].
SynonymsZopolrestatum, CP-73850, CP73850, CP 73850
Chemical Properties
Molecular Weight419.38
FormulaC19H12F3N3O3S
Cas No.110703-94-1
SmilesOC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12
Relative Density.1.58g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (26.23 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (1.19 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3845 mL11.9224 mL23.8447 mL119.2236 mL
5 mM0.4769 mL2.3845 mL4.7689 mL23.8447 mL
10 mM0.2384 mL1.1922 mL2.3845 mL11.9224 mL
20 mM0.1192 mL0.5961 mL1.1922 mL5.9612 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ZopolrestatratspotentoralInhibitorinhibitglyceraldehydeglucosediabeticAldose ReductaseAldose reductasealdose
Related Tags: buy Zopolrestat | purchase Zopolrestat | Zopolrestat cost | order Zopolrestat | Zopolrestat chemical structure | Zopolrestat in vivo | Zopolrestat in vitro | Zopolrestat formula | Zopolrestat molecular weight
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