Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Zopolrestat is a potent inhibitor of aldose Reductase (IC50 = 3.1 nM).
Description | Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM). |
Targets&IC50 | Aldose reductase:3.1 nM |
In vitro | Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1]. |
In vivo | After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1]. |
Synonyms | CP-73850, Zopolrestatum, CP73850, CP 73850 |
Molecular Weight | 419.38 |
Formula | C19H12F3N3O3S |
CAS No. | 110703-94-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 11 mg/mL (26.23 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zopolrestat 110703-94-1 Endocrinology/Hormones Metabolism Reductase CP-73850 diabetic potent glyceraldehyde Zopolrestatum glucose aldose CP73850 rats inhibit Aldose Reductase Inhibitor CP 73850 oral inhibitor