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ZT-12-037-01

Catalog No. T5597 CAS 2328073-61-4

Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).

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ZT-12-037-01, CAS 2328073-61-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 236.00
50 mg	In stock	$ 458.00
100 mg	In stock	$ 673.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Targets&IC50	STK19 (WT):23.96 nM , STK19 (D89N):27.94 nM
In vitro	ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation.
In vivo	ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo.
Animal Research	ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3.

Molecular Weight	385.5
Formula	C21H31N5O2
CAS No.	2328073-61-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41 mg/mL (106.36 mM)

References and Literature

1. Yin C, Zhu B, Zhang T, et al.Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis[J].Cell. 2019 Feb 21;176(5):1113-1127.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library GPCR Compound Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Obesity Compound Library Anti-Colorectal Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glutamine Metabolism Compound Library Protease Inhibitor Library

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Keywords

ZT-12-037-01 2328073-61-4 GPCR/G Protein MAPK Proteases/Proteasome Serine Protease Ras inhibit ZT 12 037 01 ZT1203701 Inhibitor inhibitor

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