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WS6

Catalog No. T2106 CAS 1421227-53-3

WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

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WS6, CAS 1421227-53-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 66.00
10 mg	In stock	$ 110.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 405.00
100 mg	In stock	$ 510.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 99.83%

Purity: 98%

Purity: 97.65%

Purity: 97.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Targets&IC50	Proliferation (β cells):0.28 μM
In vitro	In the RIP-DTA mouse model with β-cell ablation, oral administration of WS6 (50 mg/kg) promotes β-cell proliferation, thereby ameliorating diabetes.
In vivo	In R7T1 cells (EC50=0.28 μM), WS6 induces cell proliferation through the action on the Erb3 binding protein-1 and IκB kinase signaling pathways.
Kinase Assay	PARP assays are conducted in a buffer containing 50 mM Tris (pH 8.0), 1 mM DTT, 1.5 μM [3H]NAD+?(1.6 μCi/mmol), 200 nM biotinylated histone H1, 200 nM slDNA, and 1 nM PARP-1 or 4 nM PARP-2 enzyme. Reactions are terminated with 1.5 mM benzamide, transferred to streptavidin Flash plates, and counted using a TopCount microplate scintillation counter.
Cell Research	R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

Molecular Weight	568.59
Formula	C29H31F3N6O3
CAS No.	1421227-53-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (163.6 mM)

Ethanol: 93 mg/mL (163.6 mM)

References and Literature

1. Shen W, et al. J Am Chem Soc. 2013, 135(5), 1669-1672.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Angiogenesis related Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Anti-Diabetic Compound Library Anti-Ovarian Cancer Compound Library Pyroptosis Compound Library Anti-Colorectal Cancer Compound Library

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Keywords

WS6 1421227-53-3 Angiogenesis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors EGFR IκB/IKK inhibit Inhibitor WS 6 WS-6 inhibitor

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