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Vps34-IN-1

Catalog No. T7015 CAS 1383716-33-3

Synonyms: VPS34-IN1

Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

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Vps34-IN-1, CAS 1383716-33-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 85.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 230.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 97.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.
Targets&IC50	VPS34:25 nM
In vitro	Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1].

Synonyms	VPS34-IN1
Molecular Weight	425.91
Formula	C21H24ClN7O
CAS No.	1383716-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 79 mg/mL (185.5 mM)

DMSO: 79 mg/mL (185.5 mM)

References and Literature

1. Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27. 2. Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026. 3. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020

Citations

1. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy. 2021 Oct;17(10):3030-3047

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Highly Selective Inhibitor Library PI3K-AKT-mTOR Compound Library Autophagy Compound Library Oxidation-Reduction Compound Library Neural Regeneration Compound Library Anti-Cancer Metabolism Compound Library Stem Cell Differentiation Compound Library Neuronal Differentiation Compound Library

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Keywords

Vps34-IN-1 1383716-33-3 Autophagy PI3K/Akt/mTOR signaling PI3K inhibit Vps34IN1 Vps-34-IN-1 Inhibitor Phosphoinositide 3-kinase VPS34-IN1 Vps34 IN 1 inhibitor

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