Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 302.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
500 mg | In stock | $ 2,830.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 312.00 |
Description | UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor. |
Targets&IC50 | L3MBTL1:3.9 μM, L3MBTL4:15.6 μM, L3MBTL3:3.2 μM |
In vitro | UNC926 demonstrates a low micromolar affinity toward L3MBTL3, exhibiting an IC50 of 3.2 μM, and shows diminished affinity for other MBT domains without binding to CBX7. In a concentration-dependent manner ranging from 1-25 μM, UNC926 effectively inhibits the interaction between the 3xMBT domain and H4K20me1 and impedes the association of L3MBTL1's 3xMBT with specific histone peptides. However, it does not disrupt the binding of 53BP1 to H4K20me1, indicating that UNC926 specifically targets L3MBTL1 rather than 53BP1. |
Molecular Weight | 373.72 |
Formula | C16H22BrClN2O |
CAS No. | 1782573-49-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (444.77 mM)
You can also refer to dose conversion for different animals. More
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UNC926 hydrochloride 1782573-49-2 Chromatin/Epigenetic Epigenetic Reader Domain UNC 926 Hydrochloride UNC926 methyl-lysine L3MBTL3 UNC-926 hydrochloride L3MBTL1 Inhibitor inhibit 3xMBT UNC-926 UNC 926 H4K20me1 UNC-926 Hydrochloride UNC926 Hydrochloride inhibitor