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Trofinetide

Catalog No. T17171 CAS 853400-76-7

Synonyms: NNZ-2566

Trofinetide (NNZ-2566) is a synthetic analog of the endogenous N-terminus tripeptide. It has been shown to be neuroprotective in animal models of brain injury.

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Trofinetide, CAS 853400-76-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 303.00
10 mg	In stock	$ 459.00
25 mg	In stock	$ 755.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,430.00

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Purity: 98.70%

Biological Description

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Description

Trofinetide (NNZ-2566) is a synthetic analog of the endogenous N-terminus tripeptide. It has been shown to be neuroprotective in animal models of brain injury.

In vivo

Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI. Trofinetide suppresses penetrating ballistic-like brain injury-induced inflammatory cell infiltration at 3 days following PBBI as compared to vehicle treatment. All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals. Trofinetide treatment produces significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment significantly decreases the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%), and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. The high doses of Trofinetide (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion [1][2].

Synonyms	NNZ-2566
Molecular Weight	315.32
Formula	C13H21N3O6
CAS No.	853400-76-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 44 mg/mL (139.54 mM)

References and Literature

1. Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19. 2. Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max Pediatric Drug Library NO PAINS Compound Library Bioactive Compound Library FDA-Approved Drug Library Clinical Compound Library ReFRAME Related Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Trofinetide 853400-76-7 Others NNZ-2566 NNZ2566 NNZ 2566 Inhibitor inhibit inhibitor

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