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Trioxsalen
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Catalog No. T4558Cas No. 3902-71-4
Alias Trisoralen, Trioxysalen, Trimethylpsoralen
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
Trioxsalen
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Purity: 99.41%
Catalog No. T4558Alias Trisoralen, Trioxysalen, TrimethylpsoralenCas No. 3902-71-4
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | In Stock | In Stock | |
| 25 mg | $29 | In Stock | In Stock | |
| 50 mg | $34 | In Stock | In Stock | |
| 100 mg | $48 | In Stock | In Stock | |
| 200 mg | Inquiry | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.41%
Appearance:Solid
Color:White
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Product Introduction
Trioxsalen AI Summary
Trioxsalen exhibits a multifaceted bioactivity profile involving selective photocytotoxicity, significant antiviral properties, and enzyme inhibition. Notably, it demonstrates photocytotoxicity against UV-irradiated human LoVo cells with an EC50 of 940.0 nM and high selectivity (CC50/EC50 > 210), while showing no significant cytotoxicity in the absence of irradiation. The compound has a partition coefficient log P of 2.44 and induces pBR322 cross-linking after irradiation at activity levels below 0.5 µM. Additionally, it has antiproliferative activity against mouse EAC cells and inhibits several biological targets, including JMJD2E, ALDH1A1, ERK signaling pathway, Cytochrome P450 3A4, and others, with noted proficiency in activating Cytochrome P450 3A4.
In terms of antiviral activity, Trioxsalen inhibits the cytotoxicity induced by SARS-CoV-2 in VERO-6 and Caco-2 cells, albeit with limited efficacy indicated by an IC50 value greater than 20000.0 nM after 48-hour exposure. It also inhibits SARS-CoV-2 3CL-Pro protease by 14.8% at 20 µM. Furthermore, the compound shows inhibition in sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, significant inhibition of soybean lipoxygenase, and inhibition of NF-KB p50 subunit/DNA interaction with an IC50 of 0.5 nM.
Trioxsalen exhibits inhibitory activity against human HDAC6, acetylcholinesterase, and butyrylcholinesterase and exhibits various interactions with human receptors and enzymes, including MAOA, PTGS2, and PDE3A. Its diverse bioactivities suggest potential utility in multiple therapeutic domains, influenced by its ability to penetrate cellular membranes as indicated by a LogD7.4 value of 3.47..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death. |
| Synonyms | Trisoralen, Trioxysalen, Trimethylpsoralen |
| Molecular Weight | 228.24 |
| Formula | C14H12O3 |
| Cas No. | 3902-71-4 |
| Smiles | CC=1C2=C(C=C3C1OC(C)=C3)C(C)=CC(=O)O2 |
| Relative Density. | 1.236 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.29 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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