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Trimetazidine dihydrochloride

Catalog No. T0988   CAS 13171-25-0
Synonyms: 盐酸曲美他嗪, Yoshimilon, Kyurinett, Vastarel F

Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina.

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Trimetazidine dihydrochloride, CAS 13171-25-0
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina.
Targets&IC50 mitochondrial long-chain 3-ketoacyl thiolase:75 nM
In vitro Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3].
In vivo The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2].
Cell Research The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment. (Only for Reference)
Synonyms 盐酸曲美他嗪, Yoshimilon, Kyurinett, Vastarel F
Molecular Weight 339.26
Formula C14H24Cl2N2O3
CAS No. 13171-25-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 70 mg/mL (206.33 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kantor PF, et al. Circ Res. 2000, 86(5):580-588. 2. Liu Z, et al. Metabolism. 2016, 65(3):122-130. 3. Yang Q, et al. Int J Clin Exp Pathol. 2015, 8(4):3735-3741.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library

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Keywords

Trimetazidine dihydrochloride 13171-25-0 代谢 自噬 Autophagy Fatty Acid Synthase Kyurinett inhibit Inhibitor Vastarel F Trimetazidine Yoshimilon inhibitor