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Triclosan

Catalog No. T1314 CAS 3380-34-5

Synonyms: Cloxifenolum, Irgasan

Triclosan is an <a href="/target/Antibacterial" style="display: inline; color: #c13a36">Antibacterial</a> and <a href="/target/Antifungal" style="display: inline; color: #c13a36">Antifungal</a> agent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Triclosan, CAS 3380-34-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 33.00
50 mg	In stock	$ 43.00
100 mg	In stock	$ 46.00
200 mg	In stock	$ 84.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Triclosan is an antibacterial and antifungal agent.
In vitro	cancer cells with triclosan at the physiologically related concentrations significantly increases the colony number of the cancer cells assessed by tumor formation assay. Triclosan-treated cells have a mesenchymal-like morphology and decrease the cell-to-cell adhesion. Triclosan-treated cells exhibit decreased E-cadherin while significantly up-regulated levels of EMT markers, namely N-cadherin, vimentin, snail and slug. Triclosan may potentiate cancer cells survival in detached condition and motility via the process of EMT[2].
In vivo	Triclosan plays a pathologic role in promoting tissue fibrogenesis, leading to liver carcinogenesis. It accelerates both HCC development and its long-term effects on liver damage, accompanied by fibrosis and inflammation in mice[1].
Cell Research	CV-1 cells are maintained in DMEM supplemented with 10% FBS, seeded in 96-well plates, and transfected with an expression vector containing a specific nuclear receptor and RXR, along with a luciferase reporter containing the appropriate DNA response element. The assay is first validated with known nuclear receptor ligands as positive controls. For the CAR ligand-binding assay, CV-1 cells are transiently transfected with the expression vector containing the Gal4 DNA-binding domain fused with the ligand-binding domain of murine or human CAR and cotransfected with the luciferase reporter plasmid, mh 100-luc. The day after the transfection, the positive compound of each nuclear receptor or TCS(Triclosan) is added and the cells are incubated for an additional 24 h. The luciferase activities are measured and normalized by β-gal activity.(Only for Reference)

Synonyms	Cloxifenolum, Irgasan
Molecular Weight	289.54
Formula	C12H7Cl3O2
CAS No.	3380-34-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: >10 mM

Ethanol: 57 mg/mL (196.86 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yueh MF, et al. Proc Natl Acad Sci U S A. 2014, 111(48):17200-5. 2. Winitthana T, et al. PLoS One. 2014, 9(10):e110851. 3. Hao Z, Wu Q, Li Z, et al. Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders. Cell Research. 2019, 29(10): 866-869.

Citations

1. Hao Z, Wu Q, Li Z, et al. Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders. Cell Research. 2019, 29(10): 866-869

Related compound libraries

This product is contained In the following compound libraries：

Anti-Infection Compound Library Anti-Cancer Drug Library Pediatric Drug Library Human Metabolite Library Drug-Fragment Library NO PAINS Compound Library Anti-Fungal Compound Library RO5 Drug-like Natural Product Library Approved Drug Library Selected Plant-Sourced Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Triclosan 3380-34-5 Autophagy Metabolism Microbiology/Virology NADPH Antibiotic Antibacterial Antifungal inhibit Cloxifenolum Fungal Inhibitor Irgasan Bacterial inhibitor

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