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Taraxerol

Catalog No. TN1077   CAS 127-22-0
Synonyms: Skimmiol, Alnulin

Taraxerol(Alnulin) is an anti-inflammatory and anticancer compound derived from dandelion.Taraxerol reduces acute inflammation and induces apoptosis by inhibiting the NF-κB signaling pathway.

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Taraxerol Chemical Structure
Taraxerol, CAS 127-22-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Taraxerol(Alnulin) is an anti-inflammatory and anticancer compound derived from dandelion.Taraxerol reduces acute inflammation and induces apoptosis by inhibiting the NF-κB signaling pathway.
In vitro Taraxerol (0-100 μM; 24 or 48 hours) significantly reduced cell viability to 95% (20 μM), 89.8% (40 μM), 82.6% (60 μM), 72.9% (80 μM), and 63.6% (100 μM). The cell viability of this compound in Hela cells at 20 μM and 100 μM concentrations within 48 hours was 90.7% and 53.6%, respectively.[1]
Taraxerol (80 μM; 24 or 48 hours) induces apoptosis and cell death in HeLa cells in a dose-dependent manner. Annexin V/PI double staining method showed that compared with the number of apoptotic cells in the control group at the early (6.5%) and late (0.5%) stages, Taraxerol could significantly induce cell apoptosis (24.2% in the early stage and 16.2% in the late stage).[1]
In vivo Taraxerol (5 and 10 mg/kg; i.p.) reduces carrageenan-induced paw edema. The effect of 5mg/kg Taraxerol was significant (p<0.05) only after 4 hours of carrageenan treatment.[2]
Synonyms Skimmiol, Alnulin
Molecular Weight 426.72
Formula C30H50O
CAS No. 127-22-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: <0.1 mg/ml

THF: 5 mg/ml (11.72 mM), sonification is recommended.

H2O: <0.1 mg/ml

TargetMolReferences and Literature

1. Yaoi X, et al. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells.Cell J. 2017 Oct;19(3):512-519. 2. Khanra R, et al. Taraxerol, a pentacyclic triterpene from Abroma augusta leaf, attenuates acute inflammation via inhibition of NF-κB signaling. Biomed Pharmacother. 2017 Apr;88:918-923.

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Keywords

Taraxerol 127-22-0 Apoptosis NF-Κb NF-κB Skimmiol Alnulin inhibitor inhibit

 

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