Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 336.00 | |
100 mg | In stock | $ 493.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
Targets&IC50 | PI3Kγ:50 nM, PI3Kα:165 nM, PI3Kβ:215 nM, PI3Kδ:24 nM |
In vitro | TG 100713 also strongly inhibits EC proliferation. [1] |
Kinase Assay | Kinase Assays: PI3K reactions are constructed by using recombinant human kinases, 3 μM ATP, phosphatidylinositol substrate, and cofactors, and reaction progression measured by using a luminescent-based detection system to quantify ATP consumption. Protein kinase assays are performed by using commercial screening services. |
Cell Research | Human umbilical vein EC plated in 96-well cluster plates (5,000 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of test compounds (10 μM), and cell numbers are quantified by XTT assay.(Only for Reference) |
Synonyms | TG100713 |
Molecular Weight | 254.25 |
Formula | C12H10N6O |
CAS No. | 925705-73-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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TG 100713 925705-73-3 PI3K/Akt/mTOR signaling PI3K PI3Kβ Inhibitor PI3Kα PI3Kγ inhibit TG100713 isoform TG-100713 Phosphoinositide 3-kinase PI3Kδ inhibitor