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Spiperone

Name: Spiperone
Brand: TargetMol
SKU: T0280
Price: 92 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0280Cas No. 749-02-0

Alias Spiropitan, Spiroperidol

Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.

Spiperone

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Purity: 99.91%

Catalog No. T0280Alias Spiropitan, SpiroperidolCas No. 749-02-0

Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$92	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Color:White

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COA HNMR LCMS

Product Introduction

Spiperone AI Summary

Spiperone exhibits significant binding affinities and bioactivities across various serotonin and dopamine receptors, as well as other targets. It shows high affinity for the rat 5-hydroxytryptamine 2 receptor (Ki = 1.0 nM) and the dopamine receptor D2 (Ki = 0.045 nM). Additionally, it has moderate to high binding affinity for several other serotonin receptors including 5-HT1A, 5-HT7, and 5-HT2A, with Ki values of 30.0 nM, 19.95 nM, and 1.8 nM, respectively. The compound also exhibits strong inhibitory activity against dopamine D3 and D4 receptors with Ki values of 0.25 nM and 0.33 nM, respectively, and demonstrates potential multi-target activity across dopaminergic and serotonergic systems. Furthermore, Spiperone shows high potency in displacing radioligands from dopamine D2 receptors (IC50 = 0.06 nM) and a significant selectivity towards these receptors compared to others. In terms of adrenergic receptors, it displays notable affinity for the Alpha-1A adrenergic receptor (Ki = 7.2 nM). The compound has demonstrated cardiotoxic effects, such as QTc prolongation in guinea pigs, and exhibits various bioactivities, including inhibition of sodium fluorescein uptake and displacement of [3H]BTX-B from sodium channels. It has also shown antiviral activity, inhibiting SARS-CoV-2 replication in vitro with IC50 values around 20400.0 nM. Overall, the diverse range of bioactivities associated with Spiperone suggests its potential therapeutic applications in neurological disorders, psychiatric conditions, and possibly antiviral treatments, while also highlighting the need for careful consideration of its cardiotoxicity and broad receptor interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
Synonyms	Spiropitan, Spiroperidol

Chemical Properties

Molecular Weight	395.47
Formula	C₂₃H₂₆FN₃O₂
Cas No.	749-02-0
Smiles	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Relative Density.	1.1714 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (63.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5286 mL	12.6432 mL	25.2864 mL	126.4318 mL
5 mM	0.5057 mL	2.5286 mL	5.0573 mL	25.2864 mL
10 mM	0.2529 mL	1.2643 mL	2.5286 mL	12.6432 mL
20 mM	0.1264 mL	0.6322 mL	1.2643 mL	6.3216 mL
50 mM	0.0506 mL	0.2529 mL	0.5057 mL	2.5286 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc