Shopping Cart

Your shopping cart is currently empty

Sodium 4-phenylbutyrate

Name: Sodium 4-phenylbutyrate
Brand: TargetMol
SKU: T1535
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1535Cas No. 1716-12-7

Alias TriButyrate, Sodium Phenylbutyrate, Buphenyl

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

Sodium 4-phenylbutyrate

Copy Product Info

🥰Excellent

Purity: 99.92%

Catalog No. T1535Alias TriButyrate, Sodium Phenylbutyrate, BuphenylCas No. 1716-12-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$54	In Stock	In Stock
200 mg	$87	In Stock	In Stock
500 mg	$144	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
In vitro	In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.
In vivo	In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
Synonyms	TriButyrate, Sodium Phenylbutyrate, Buphenyl

Chemical Properties

Molecular Weight	186.18
Formula	C₁₀H₁₁NaO₂
Cas No.	1716-12-7
Smiles	[Na+].[O-]C(=O)CCCc1ccccc1
Relative Density.	1.095g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 33.33 mg/mL (179.02 mM), Sonication is recommended.

DMSO: 33.33 mg/mL (179.02 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3711 mL	26.8557 mL	53.7115 mL	268.5573 mL
5 mM	1.0742 mL	5.3711 mL	10.7423 mL	53.7115 mL
10 mM	0.5371 mL	2.6856 mL	5.3711 mL	26.8557 mL
20 mM	0.2686 mL	1.3428 mL	2.6856 mL	13.4279 mL
50 mM	0.1074 mL	0.5371 mL	1.0742 mL	5.3711 mL
100 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6856 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc