Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
Description | Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA . |
In vitro | The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column. |
Molecular Weight | 272.4 |
Formula | C19H16N2 |
CAS No. | 6882-99-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: <2.73 mg/mL (10 mM), Need ultrasound
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Sempervirine 6882-99-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Inhibitor inhibitor inhibit