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Sappanchalcone

Catalog No. TN2180   CAS 94344-54-4

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

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Sappanchalcone Chemical Structure
Sappanchalcone, CAS 94344-54-4
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1 mg 5 days $ 291.00
5 mg 5 days $ 813.00
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Purity: 97.00%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
In vitro The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on the cell cycle was determined by flow cytometric analysis. The anti-tumor activities were assessed in vitro and in vivo. The EtOAc extract of Lignum Sappan had inhibitory activities on growth-related signaling and cell mitosis. Three major active compounds were Sappanchalcone, brazilin, and butein. Sappanchalcone blocked cell cycle progression in the G2/M phase, brazilin inhibited TNFα±/NF-κB signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNFα±/NF-κB signaling. The three compounds all demonstrated cytotoxic activities against human tumor cells in vitro. In a S180 tumor cell-bearing mice model, the anti-tumor efficacy of the EtOAc extract was better than the individual compounds acting alone[1]
Source
Molecular Weight 286.28
Formula C16H14O5
CAS No. 94344-54-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells.Chin J Nat Med. 2014 Aug;12(8):607-12.

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Keywords

Sappanchalcone 94344-54-4 Apoptosis Immunology/Inflammation TNF IL Receptor BCL inhibitor inhibit

 

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