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Rutaecarpine

Catalog No. T2972 CAS 84-26-4

Synonyms: Rutacarpine, Rhetine, Rutecarpine

Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Rutaecarpine, CAS 84-26-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 33.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 95.00
50 mg	In stock	$ 135.00
100 mg	In stock	$ 196.00
500 mg	In stock	$ 487.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 97.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
Targets&IC50	COX-2:0.28 μM.
In vitro	Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. [1]
Cell Research	Rutaecarpine is dissolved in DMSO and diluted with appropriate medium before use. COX-1 and COX-2 cDNA-transfected HEK293 cells are prepared. For measuring inhibitory activity on COX-1 and COX-2 by rutaecarpine, cells in 1 mL of culture medium are seeded into each well of 24-well. After culture for 4 days, the supernatants are removed and 250 mL of fresh medium is added to the cells with or without rutaecarpine. After preincubation for 5 h at 37°C, the cells are further incubated at 37°C for 30 min with 50 mM arachidonic acid. All reactions are stopped by centrifugation at 120 g at 4°C for 5 min. Concentrations of PGE2 in the supernatant are measured[1].
Source	Natural Products > Cornaceae > Cornus

Synonyms	Rutacarpine, Rhetine, Rutecarpine
Molecular Weight	287.32
Formula	C18H13N3O
CAS No.	84-26-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 23 mg/mL (80.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Lee SH, et al. Molecules, 2008, 13(2), 272-300. 2. Yang XW, et al. J Asian Nat Prod Res, 2006, 8(8), 697-703. 3. Moon TC, et al. Inflamm Res. 1999, 48(12):621-5.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Neuronal Signaling Compound Library HIF-1 Signaling Pathway Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Immunology/Inflammation Compound Library Anti-Tumor Natural Product Library Anti-Gastroenteritis Natural Product Library Pyroptosis Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max

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Keywords

Rutaecarpine 84-26-4 Immunology/Inflammation Neuroscience COX Rutacarpine Inhibitor inhibit Rhetine Cyclooxygenase Rutecarpine inhibitor

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