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Prostaglandin E2

Catalog No. T5014 CAS 363-24-6

Synonyms: PGE2, Dinoprostone, Prostaglandin E2 (PGE2)

Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, regulation of blood pressure, and inflammatory regulation.

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Prostaglandin E2, CAS 363-24-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 94.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 379.00
100 mg	In stock	$ 589.00
500 mg	In stock	$ 1,280.00
1 g	In stock	$ 1,720.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.95%

Purity: 99.92%

Purity: 99.76%

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Description	Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, regulation of blood pressure, and inflammatory regulation.
In vitro	METHODS: Human colorectal cancer cells LS-174T were treated with Prostaglandin E2 (0.05-10 μM) for 1-60 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Prostaglandin E2 induced phosphorylation of Akt as early as 1 min after stimulation, and the activation of Akt reached a maximum within 10 min and persisted until 60 min. The addition of Prostaglandin E2 activated Akt in a dose-dependent manner. [1] METHODS: FDC-like cells were treated with Prostaglandin E2 (1 μM) for 15-120 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Prostaglandin E2 did not increase p-ERK, but decreased p-ERK at 60 and 120 min. on the contrary, p-p38 increased starting at 15 min and continued to 60 min. [2]
In vivo	METHODS: To test the role of EP2 receptors in the in vivo absorption response, Prostaglandin E2 (3 mg/kg) was injected subcutaneously four times daily for three days into EP2+/+ and EP2-/- mice on a 129/SvEv background. RESULTS: Prostaglandin E2 increased serum calcium from 9.8+/-0.5 to 10.7+/-0.3 mg/dL in EP2+/+ mice but not in EP2-/- mice. [3] METHODS: To study the effects on bone, Prostaglandin E2 (6 mg/kg) was injected subcutaneously into C57BL/6 mice once daily for 3-12 days. RESULTS: Prostaglandin E2-treated mice showed a decrease in trabecular bone volume (BV/TV) at 14 days, indicating increased bone resorption. However, the Prostaglandin E2-treated 3-day group also stimulated bone formation at 14 days due to increased mineral deposition rate (MAR) and bone formation rate (BFR/BS). [4]

Synonyms	PGE2, Dinoprostone, Prostaglandin E2 (PGE2)
Molecular Weight	352.47
Formula	C20H32O5
CAS No.	363-24-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35.3 mg/mL(100 mM)

References and Literature

1. Buchanan FG, et al. Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem. 2003 Sep 12;278(37):35451-7. 2. Cho W, et al. Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells. BMC Immunol. 2020 Apr 17;21(1):20. 3. Li X, et al. Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo. Prostaglandins Other Lipid Mediat. 2002 Apr;67(3-4):173-80. 4. Gao Q, et al. Effects of prostaglandin E2 on bone in mice in vivo. Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):20-5.

Citations

1. Wang M, Wang X, Jiang B, et al. Identification of MRAP protein family as broad‐spectrum GPCR modulators. Clinical and Translational Medicine. 2022, 12(11): e1091. 2. Tang C, Sun H, Kadoki M, et al.Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.Nature Communications.2023, 14(1): 1493. 3. Chen S, Wu Y, Gao Y, et al.Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness.Cell Reports.2023, 42(10): 113246. 4. Zhao M, Wu J, Jin Y, et al.Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1. 7 channels and Cav2. 2 channels.Journal of Ethnopharmacology.2024: 117996.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Human Endogenous Metabolite Library Traditional Chinese Medicine Monomer Library Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-COVID-19 Compound Library Natural Product Library for HTS

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Keywords

Prostaglandin E2 363-24-6 GPCR/G Protein Immunology/Inflammation Metabolism Endogenous Metabolite Prostaglandin Receptor Prostaglandin E-2 inhibit PGE2 Dinoprostone Prostaglandin E 2 Inhibitor PGE-2 PGE 2 Prostaglandin E2 (PGE2) inhibitor

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