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PEAQX tetrasodium hydrate

PEAQX tetrasodium hydrate
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PEAQX tetrasodium hydrate

Catalog No. T16451
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
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Pack SizePriceAvailabilityQuantity
1 mg$71In Stock
5 mg$167In Stock
10 mg$250In Stock
25 mg$430In Stock
50 mg$636In Stock
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Product Introduction

Bioactivity
Description
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
In vitro
PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM).[1]
In vivo
PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1].
Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to the PCP challenge on PN28-PN35.[2]
AliasNVP-AAM077 tetrasodium hydrate, PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate
Chemical Properties
Molecular Weight560.15
FormulaC17H15BrN3Na4O6P
Cas No.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 22.9 mg/mL (41.0 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
50 mM0.0357 mL0.1785 mL0.3570 mL1.7852 mL
100 mM0.0179 mL0.0893 mL0.1785 mL0.8926 mL

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