Shopping Cart

Remove All
Your shopping cart is currently empty

PD-1/PD-L1-IN-10

Name: PD-1/PD-L1-IN-10
Brand: TargetMol
SKU: T9616
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9616Cas No. 2487550-41-2

PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.

PD-1/PD-L1-IN-10

🥰Excellent

Purity: 99.63%

Catalog No. T9616Cas No. 2487550-41-2

PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$172	In Stock
25 mg	$333	In Stock
50 mg	$597	In Stock
100 mg	$852	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.63%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.
Targets&IC50	PD-1/PD-L1:2.7 nM
In vitro	PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, starting at 1 nM, without compromising the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. It significantly stabilizes PD-L1 protein levels in LLC cells within the 0-100 nM range, showing a dose-dependent effect on PD-L1 stability at 58 °C, suggesting penetration and direct interaction with PD-L1[1].
In vivo	PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy by effectively blocking tumor cell proliferation and inducing apoptosis in LLC tumor tissues in an LLC-bearing allograft mouse model.[1]

Chemical Properties

Molecular Weight	581.62
Formula	C₃₃H₃₁N₃O₇
Cas No.	2487550-41-2
Smiles	CC(O)[C@H](NCc1cc(c(OCc2cccc(c2C)-c2ccccc2)cc1OCc1cccc(c1)C#N)[N+]([O-])=O)C(O)=O
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7193 mL	8.5967 mL	17.1934 mL	85.9668 mL
5 mM	0.3439 mL	1.7193 mL	3.4387 mL	17.1934 mL
10 mM	0.1719 mL	0.8597 mL	1.7193 mL	8.5967 mL
20 mM	0.0860 mL	0.4298 mL	0.8597 mL	4.2983 mL
50 mM	0.0344 mL	0.1719 mL	0.3439 mL	1.7193 mL
100 mM	0.0172 mL	0.0860 mL	0.1719 mL	0.8597 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc