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Catalog No. T9616Cas No. 2487550-41-2
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$98In Stock
10 mg$172In Stock
25 mg$333In Stock
50 mg$597In Stock
100 mg$852In Stock
1 mL x 10 mM (in DMSO)$116In Stock
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Related Compound Libraries of "PD-1/PD-L1-IN-10"

Product Introduction

PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
In vitro
PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, even at a minimal concentration of 1 nM[1]. It does not compromise the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. Furthermore, this compound significantly stabilizes PD-L1 protein levels within LLC cells across a range of 0-100 nM, demonstrating a dose-dependent effect on PD-L1 protein stability at 58 °C. This suggests that PD-1/PD-L1-IN-10 (compound B2) can penetrate LLC cells and directly interact with PD-L1 protein[1].
In vivo
PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy in an LLC-bearing allograft mouse model. PD-1/PD-L1-IN-10 (compound B2) effectively blocks tumor cell proliferation and induces apoptosis in LLC tumor tissues.[1].
Chemical Properties
Molecular Weight581.62
Cas No.2487550-41-2
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (171.93 mM)
Solution Preparation Table
1 mM1.7193 mL8.5967 mL17.1934 mL85.9668 mL
5 mM0.3439 mL1.7193 mL3.4387 mL17.1934 mL
10 mM0.1719 mL0.8597 mL1.7193 mL8.5967 mL
20 mM0.0860 mL0.4298 mL0.8597 mL4.2983 mL
50 mM0.0344 mL0.1719 mL0.3439 mL1.7193 mL
100 mM0.0172 mL0.0860 mL0.1719 mL0.8597 mL


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