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PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10
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PD-1/PD-L1-IN-10

Catalog No. T9616Cas No. 2487550-41-2
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
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Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$98In Stock
10 mg$172In Stock
25 mg$333In Stock
50 mg$597In Stock
100 mg$852In Stock
1 mL x 10 mM (in DMSO)$116In Stock
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Product Introduction

Bioactivity
Description
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
In vitro
PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, even at a minimal concentration of 1 nM[1]. It does not compromise the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. Furthermore, this compound significantly stabilizes PD-L1 protein levels within LLC cells across a range of 0-100 nM, demonstrating a dose-dependent effect on PD-L1 protein stability at 58 °C. This suggests that PD-1/PD-L1-IN-10 (compound B2) can penetrate LLC cells and directly interact with PD-L1 protein[1].
In vivo
PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy in an LLC-bearing allograft mouse model. PD-1/PD-L1-IN-10 (compound B2) effectively blocks tumor cell proliferation and induces apoptosis in LLC tumor tissues.[1].
Chemical Properties
Molecular Weight581.62
FormulaC33H31N3O7
Cas No.2487550-41-2
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (171.93 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7193 mL8.5967 mL17.1934 mL85.9668 mL
5 mM0.3439 mL1.7193 mL3.4387 mL17.1934 mL
10 mM0.1719 mL0.8597 mL1.7193 mL8.5967 mL
20 mM0.0860 mL0.4298 mL0.8597 mL4.2983 mL
50 mM0.0344 mL0.1719 mL0.3439 mL1.7193 mL
100 mM0.0172 mL0.0860 mL0.1719 mL0.8597 mL

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