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Microbiology/Virology Ribosome Oxytetracycline

Oxytetracycline

Catalog No. T0895   CAS 79-57-2
Synonyms: Terramycin

Oxytetracycline is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Oxytetracycline, CAS 79-57-2
Pack Size Availability Price/USD Quantity
25 mg In stock 38.00
50 mg In stock 52.00
100 mg In stock 72.00
200 mg In stock 129.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 98.25%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxytetracycline is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
Targets&IC50 16S ribosome ,   30S ribosome
In vivo Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. [1] Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). [2]
Synonyms Terramycin
Purity 98.25%
Molecular Weight 460.44
Formula C22H24N2O9
CAS No. 79-57-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 85 mg/mL (184.6 mM)

Ethanol: 10 mg/mL (21.71 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Pari L, et al. Basic Clin Pharmacol Toxicol, 2006, 98(5), 456-461. 2. Jayanthi R, et al. Indian J Clin Biochem, 2010, 25(4), 371-375. 3. Idris S B, Kadir A A, Abdullah J F F, et al. Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice[J]. Frontiers in Veterinary Science. 2020, 7. 4. Khan K Y, Ali B, Zhang S, et al. Effects of antibiotics stress on growth variables, ultrastructure, and metabolite pattern of Brassica rapa ssp. Chinensis[J]. Science of The Total Environment. 2021: 146333.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Natural Compound Library for HTS Anti-infection Compound Library Anti-virus Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library Antibiotics Library Microbial Natural Product Library Anti-aging Compound Library Drug Repurposing Library Antibacterial Activity Library Ferroptosis Compound Library Anti-COVID-19 Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library

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