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Oxytetracycline

Catalog No. T0895   CAS 79-57-2
Synonyms: Terramycin

Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

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Oxytetracycline Chemical Structure
Oxytetracycline, CAS 79-57-2
Pack Size Availability Price/USD Quantity
25 mg In stock $ 36.00
50 mg In stock $ 46.00
100 mg In stock $ 64.00
200 mg In stock $ 108.00
500 mg In stock $ 178.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 98.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
In vivo Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. [1] Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). [2]
Synonyms Terramycin
Molecular Weight 460.43
Formula C22H24N2O9
CAS No. 79-57-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 85 mg/mL (184.6 mM)

Ethanol: 10 mg/mL (21.71 mM)

TargetMolReferences and Literature

1. Pari L, et al. Basic Clin Pharmacol Toxicol, 2006, 98(5), 456-461. 2. Jayanthi R, et al. Indian J Clin Biochem, 2010, 25(4), 371-375. 3. Idris S B, Kadir A A, Abdullah J F F, et al. Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice[J]. Frontiers in Veterinary Science. 2020, 7. 4. Khan K Y, Ali B, Zhang S, et al. Effects of antibiotics stress on growth variables, ultrastructure, and metabolite pattern of Brassica rapa ssp. Chinensis[J]. Science of The Total Environment. 2021: 146333.

TargetMolCitations

1. Khan K Y, Ali B, Zhang S, et al. Effects of antibiotics stress on growth variables, ultrastructure, and metabolite pattern of Brassica rapa ssp. Chinensis. Science of The Total Environment. 2021 Jul 15;778:146333. doi: 10.1016/j.scitotenv.2021.146333. Epub 2021 Mar 11. 2. Khan K Y, Ali B, Zhang S, et al. Phytotoxic effects on chloroplast and UHPLC-HRMS based untargeted metabolomic responses in Allium tuberosum Rottler ex Sprengel (Chinese leek) exposed to antibiotics. Ecotoxicology and Environmental Safety. 2022, 234: 113418. 3. Idris S B, Kadir A A, Abdullah J F F, et al. Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice. Frontiers in Veterinary Science. 2020, 7

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Drug-induced Liver Injury (DILI) Compound Library Covalent Inhibitor Library Human Metabolite Library FDA-Approved Drug Library Orally Active Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library Natural Product Library

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Keywords

Oxytetracycline 79-57-2 Metabolism Microbiology/Virology ribosome HSV Antibiotic Endogenous Metabolite Antibacterial Gram-positive protein HSV-1 synthesis tetracycline Herpes simplex virus inhibit m-ribosomal Gram-negative Bacterial Inhibitor Terramycin aminoacil-tRNA inhibitor

 

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