Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
2 mg | In stock | $ 108.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | $ 312.00 | |
25 mg | In stock | $ 539.00 | |
50 mg | In stock | $ 778.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 197.00 |
Description | Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
Targets&IC50 | PARP1:2.4 nM |
In vitro | Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). [1]. |
Synonyms | MK 4827 (R-enantiomer), Niraparib R-enantiomer |
Molecular Weight | 320.39 |
Formula | C19H20N4O |
CAS No. | 1038915-58-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (93.63 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Niraparib (R-enantiomer) 1038915-58-0 Chromatin/Epigenetic DNA Damage/DNA Repair PARP MK 4827 MK-4827 MK4827 MK 4827 (R-enantiomer) poly ADP ribose polymerase Inhibitor Niraparib (R enantiomer) Niraparib (Renantiomer) Niraparib R-enantiomer Niraparib inhibit inhibitor