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Naproxen

Name: Naproxen
Brand: TargetMol
SKU: T1582
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1582Cas No. 22204-53-1

Alias (S)-Naproxen

Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.

Naproxen

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Purity: 99.89%

Catalog No. T1582Alias (S)-NaproxenCas No. 22204-53-1

Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$42	-	In Stock
5 g	$48	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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COA HNMR LCMS

Product Introduction

Naproxen AI Summary

Naproxen exhibits a comprehensive range of bioactivities and physicochemical properties relevant to pharmacological research. It demonstrates significant binding affinity to human serum albumin with a binding constant of Log K' = 0.25, indicating specific interaction potential. The compound shows effective permeability in humans with a Peff value of 8.3, a pKa value of 4.01, and a log P of 3.58, which suggests favorable absorption characteristics. Its bioactivity profile includes inhibition of prostaglandin synthetase in mouse brain microsomes (IC50 of 13,000 nM), superior anti-inflammatory properties (COX-1 IC50 at 2,700 nM, and COX-2 IC50 at 9,700 nM), and analgesic effects in several inflammation models such as adjuvant-induced arthritis with an ED50 of 0.94 mg/kg. Naproxen also exhibits interactions with cellular targets like the Thyroid Stimulating Hormone Receptor and Mitochondrial Division, indicating broad bioactivity. It displays anti-inflammatory activity with an 81.81% inhibition of carrageenan-induced paw edema in rats at 30 mg/kg and low ulcerogenic activity with a UI of 2.25 at 90 mg/kg. The compound has been observed to interact with lipid peroxidation processes and shows a favorable therapeutic index. Furthermore, Naproxen selectively inhibits COX enzymes, with a higher potency for COX-1 (IC50 at 11,000 nM) over COX-2 (IC50 at 1,010,000 nM), suggesting specific anti-inflammatory action. It also exhibits anti-nociceptive effects and potential hepatotoxicity based on enzyme activity and liver function tests. Its binding affinity to amyloid beta fibrils (Ki of 5.7 nM) suggests possible applications in neurodegenerative disease research. Pharmacokinetically, it shows high bioavailability with extensive binding to plasma proteins (log K of 3.34 in octanol-water partitioning). The compound displays efficient inhibition of various enzymatic pathways (notably aIC50 of 480 nM for AKR1C3) and low permeability across certain membrane models. Overall, Naproxen presents a multi-faceted bioactivity profile with potential therapeutic implications across inflammation, pain relief, and possibly neurodegeneration, meriting further detailed pharmacological and toxicological investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
Targets&IC50	COX-2:5.15 μM, COX-1:8.72 μM
Synonyms	(S)-Naproxen

Chemical Properties

Molecular Weight	230.26
Formula	C₁₄H₁₄O₃
Cas No.	22204-53-1
Smiles	[C@H](C(O)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
Relative Density.	1.1450 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1085.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3429 mL	21.7146 mL	43.4292 mL	217.1458 mL
5 mM	0.8686 mL	4.3429 mL	8.6858 mL	43.4292 mL
10 mM	0.4343 mL	2.1715 mL	4.3429 mL	21.7146 mL
20 mM	0.2171 mL	1.0857 mL	2.1715 mL	10.8573 mL
50 mM	0.0869 mL	0.4343 mL	0.8686 mL	4.3429 mL
100 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1715 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc