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Maprotiline hydrochloride

Catalog No. T0172 CAS 10347-81-6

Synonyms: 盐酸马普替林, Psymion, Maprotiline HCl, Deprilept, Ludiomil

Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

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Maprotiline hydrochloride, CAS 10347-81-6

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Purity: 98%

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Storage & Solubility Information

Description	Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
In vitro	Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3]
In vivo	Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6]

Synonyms	盐酸马普替林, Psymion, Maprotiline HCl, Deprilept, Ludiomil
Molecular Weight	313.87
Formula	C20H24ClN
CAS No.	10347-81-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 23 mg/mL (73.3 mM)

H2O: <1 mg/mL

DMSO: 59 mg/mL (188 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ferrer-Villada T, et al. Eur J Pharmacol,2006, 531(1-3), 1-8. 2. Arenas MC, et al. Behav Brain Res,2006, 166(1), 150-158. 3. Jan CR, et al. Toxicology,2013, 304, 1-12. 4. Chang KL, et al. Cancer Lett. 2009 Apr 8;276(1):14-20. 5. Hajhashemi V, et al. Inflamm Res,2010, 59(12), 1053-1059.

Related compound libraries

This product is contained In the following compound libraries：

Autophagy Compound Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Serotonin Receptor-Targeted Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

Maprotiline hydrochloride 10347-81-6 G蛋白偶联受体免疫与炎症神经科学自噬 5-HT Receptor AChR Adrenergic Receptor Autophagy Histamine Receptor Norepinephrine Maprotiline Inhibitor Psymion inhibit Deprilept Maprotiline HCl Ludiomil inhibitor

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