Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Description | Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. |
In vitro | Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3] |
In vivo | Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6] |
Synonyms | 盐酸马普替林, Psymion, Maprotiline HCl, Deprilept, Ludiomil |
Molecular Weight | 313.87 |
Formula | C20H24ClN |
CAS No. | 10347-81-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 23 mg/mL (73.3 mM)
H2O: <1 mg/mL
DMSO: 59 mg/mL (188 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Maprotiline hydrochloride 10347-81-6 G蛋白偶联受体 免疫与炎症 神经科学 自噬 5-HT Receptor AChR Adrenergic Receptor Autophagy Histamine Receptor Norepinephrine Maprotiline Inhibitor Psymion inhibit Deprilept Maprotiline HCl Ludiomil inhibitor