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Metabolism Endogenous Metabolite Loxapine

Loxapine

Catalog No. T21629   CAS 1977-10-2

Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class and structurally related to clozapine (which belongs to the chemically akin class of dibenzodiazepines).

Loxapine, CAS 1977-10-2
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
50 mg In stock 132.00
100 mg In stock 198.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class and structurally related to clozapine (which belongs to the chemically akin class of dibenzodiazepines).
In vitro
In vivo
Molecular Weight 327.81
Formula C18H18ClN3O
CAS No. 1977-10-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 30 mg/mL (91.52 mM)

DMSO: 32.33 mg/mL(98.62 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. 1. Berardis D D , Fornaro M , Orsolini L , et al. The Role of Inhaled Loxapine in the Treatment of Acute Agitation in Patients with Psychiatric Disorders: A Clinical Review[J]. International Journal of Molecular ences, 2017, 18(2):349. 2. Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4. 2. Labuzek K, et al. Eur Neuropsychopharmacol, 2005, 15(1), 23-30. 3. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. 3. Lee T, et al. Psychiatry Res, 1984, 12(4), 277-285.

Related Products

Related compounds with same targets
4-Methylbiphenyl Indolelactic acid Campesterol Norgestimate metabolite Norelgestromin H-Val-Ala-OH Loxapine N-Acetyl-L-tryptophan 1-Methylhistamine dihydrochloride

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.