store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 79.00 | |
10 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. |
Targets&IC50 | PRMT5:(ki)6 nM, PRMT5:22 nM, MEP50:(ki)6 nM, MEP50:22 nM |
In vitro | LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM[1]. |
In vivo | LLY-283 administered orally at a dose of 20 mg/kg daily significantly inhibits tumor growth in A375 cell-bearing mice over a 28-day treatment period[1]. |
Molecular Weight | 342.35 |
Formula | C17H18N4O4 |
CAS No. | 2040291-27-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 3.57 mg/mL (10.43 mM), Sonication and heating to 60℃ are recommended.
DMSO: 112.5 mg/mL (328.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LLY-283 2040291-27-6 Chromatin/Epigenetic Histone Methyltransferase LLY283 LLY 283 inhibitor inhibit