Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 87.00 | |
25 mg | In stock | $ 173.00 | |
50 mg | In stock | $ 256.00 | |
100 mg | In stock | $ 379.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 92.00 |
Description | LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM. |
Targets&IC50 | CDK9:44±10 nM |
In vitro | LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo?RNA synthesis of cellular genes.[1] |
Kinase Assay | The fluorescence resonance energy transfer (FRET)-based LANCE Ultra KinaSelect Ser/Thr kit is used to determine IC50 values for various CDK inhibitors. Briefly, a specific ULight MBP peptide substrate (50 nM final concentration) is phosphorylated by a CDK-cyclin pair in buffer (50 mM HEPES-KOH pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM dithiothreitol) containing ATP at the concentration of the Km values of the individual kinases for 1 h at room temperature. Subsequently, phosphorylation is detected by addition of specific Eu-labelled anti-phospho-antibodies (2 nM), which upon binding to the phosphopeptide give rise to a FRET signal. FRET signals are then recorded[1]. |
Synonyms | LDC067 |
Molecular Weight | 370.43 |
Formula | C18H18N4O3S |
CAS No. | 1073485-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LDC000067 1073485-20-7 Apoptosis Cell Cycle/Checkpoint CDK LDC067 LDC 067 LDC-000067 Cyclin dependent kinase LDC 000067 inhibit Inhibitor LDC-067 inhibitor