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LDC000067

Catalog No. T6563   CAS 1073485-20-7
Synonyms: LDC067

LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.

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LDC000067 Chemical Structure
LDC000067, CAS 1073485-20-7
Pack Size Availability Price/USD Quantity
2 mg In stock $ 38.00
5 mg In stock $ 48.00
10 mg In stock $ 87.00
25 mg In stock $ 173.00
50 mg In stock $ 256.00
100 mg In stock $ 379.00
1 mL * 10 mM (in DMSO) In stock $ 92.00
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Purity: 99.07%
Purity: 98.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
Targets&IC50 CDK9:44±10 nM
In vitro LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo?RNA synthesis of cellular genes.[1]
Kinase Assay The fluorescence resonance energy transfer (FRET)-based LANCE Ultra KinaSelect Ser/Thr kit is used to determine IC50 values for various CDK inhibitors. Briefly, a specific ULight MBP peptide substrate (50 nM final concentration) is phosphorylated by a CDK-cyclin pair in buffer (50 mM HEPES-KOH pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM dithiothreitol) containing ATP at the concentration of the Km values of the individual kinases for 1 h at room temperature. Subsequently, phosphorylation is detected by addition of specific Eu-labelled anti-phospho-antibodies (2 nM), which upon binding to the phosphopeptide give rise to a FRET signal. FRET signals are then recorded[1].
Synonyms LDC067
Molecular Weight 370.43
Formula C18H18N4O3S
CAS No. 1073485-20-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 69 mg/mL (186.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.

TargetMolCitations

1. Jiang L, Yu Y, Li Z, et al.BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1.Viruses.2023, 15(8): 1642.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Bioactive Compound Library Inhibitor Library Apoptosis Compound Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Anti-Aging Compound Library Bioactive Compounds Library Max

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CDK9-IN-7 LRRK2 inhibitor 1 Cirtuvivint Voruciclib bio-THZ1 Amsilarotene Avotaciclib hydrochloride NVP-2

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Keywords

LDC000067 1073485-20-7 Apoptosis Cell Cycle/Checkpoint CDK LDC067 LDC 067 LDC-000067 Cyclin dependent kinase LDC 000067 inhibit Inhibitor LDC-067 inhibitor

 

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