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Kanamycin A

Catalog No. T0793L CAS 59-01-8

Synonyms: Kanamycin A, Kanamycine, Kantrex

Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin is an aminoglycoside bacteriocidal antibiotic and used to treat a wide variety of infections. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes.

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Kanamycin A, CAS 59-01-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin is an aminoglycoside bacteriocidal antibiotic and used to treat a wide variety of infections. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes.
In vitro	The concentration of Kanamycin above 0.0025% has a significant inhibition on the growth of B. bifidum while having no influence on the other four probiotics at incubation 12 h or 24 h. The optimum selective concentration of kanamycin in MRS media is 0.005% for selective enumeration of B.bifidum[3].
In vivo	The neurons damage of the DCN induced by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner[1]. Kanamycin (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin concentration exceeds 2 mg/mL for 7 h in the pony[2].

Synonyms	Kanamycin A, Kanamycine, Kantrex
Molecular Weight	484.503
Formula	C18H36N4O11
CAS No.	59-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Fan GR, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. 2. Mohamed el SW, et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4. 3. Guo WS, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493.

Related Products

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Oxytetracycline Lincomycin hydrochloride Lefamulin acetate Amikacin Spectinomycin dihydrochloride Hygromycin B Kanamycin sulfate Kanamycin

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Keywords

Kanamycin A 59-01-8 Microbiology/Virology ribosome Antibiotic Antibacterial Kanamycin Kanamycin free base Kanamycine Kantrex inhibitor inhibit

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