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Kanamycin sulfate

Catalog No. T0793   CAS 25389-94-0
Synonyms: Kanamycin monosulfate, Kanamycin A monosulfate, Ophtalmokalixan

Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside bacteriocidal antibiotic.

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Kanamycin sulfate Chemical Structure
Kanamycin sulfate, CAS 25389-94-0
Pack Size Availability Price/USD Quantity
200 mg In stock $ 41.00
1 mL * 10 mM (in H2O) In stock $ 50.00
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Purity: 99.96%
Purity: 99.63%
Purity: 99.5%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside bacteriocidal antibiotic.
In vitro The concentration of Kanamycin sulfate above 0.0025% has a significant inhibition on the growth of B. bifidum while having no influence on the other four probiotics at incubation 12 h or 24 h. The optimum selective concentration of kanamycin sulfate in MRS media is 0.005% for selective enumeration of B.bifidum[3].
In vivo The neurons damage of the DCN induced by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner[1]. Kanamycin sulfate (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeds 2 mg/mL for 7 h in the pony[2].
Synonyms Kanamycin monosulfate, Kanamycin A monosulfate, Ophtalmokalixan
Molecular Weight 582.58
Formula C18H38N4O15S
CAS No. 25389-94-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

TargetMolReferences and Literature

1. Fan GR, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. 2. Mohamed el SW, et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4. 3. Guo WS, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493. 4. Firth EC, et al. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Clinical Compound Library Saccharide and Glycoside Natural Product Library Approved Drug Library Immunology/Inflammation Compound Library Natural Product Library for HTS Anti-Infection Compound Library FDA-Approved & Pharmacopeia Drug Library Natural Product Library ReFRAME Related Library

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Keywords

Kanamycin sulfate 25389-94-0 Microbiology/Virology ribosome Antibacterial Antibiotic bovine tubercle bacilli mycobacteria inhibit Kanamycin A Kanamycin tuberculosis Kanamycin Monosulfate Kanamycin A Monosulfate K. pneumonia Kanamycin monosulfate Bacterial Kanamycin Sulfate Inhibitor Kanamycin A monosulfate Ophtalmokalixan pneumonia streptomycin inhibitor

 

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