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Amikacin
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Catalog No. T1013Cas No. 37517-28-5
Alias Amikacinum, Amikacine, Amikacina
Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin.
Amikacin
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Purity: 99.34%
Catalog No. T1013Alias Amikacinum, Amikacine, AmikacinaCas No. 37517-28-5
Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $30 | In Stock | In Stock | |
| 50 mg | $42 | In Stock | In Stock | |
| 100 mg | $68 | In Stock | In Stock | |
| 500 mg | $163 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.34%
Color:White
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Product Introduction
Amikacin AI Summary
Amikacin exhibits a broad spectrum of antibacterial and antimycobacterial activities against various clinically significant bacterial strains. It shows potent activity against multiple strains of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 256.0 µg/mL. The compound is effective against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, demonstrating lower MIC values against sensitive strains and higher values against resistant isolates. It also shows significant efficacy against Mycobacterium tuberculosis strains, including multidrug-resistant variants, with MIC values as low as 0.5 µg/mL.
In addition to its antibacterial effects, Amikacin exhibits moderate to high potency against various Mycobacterium species such as Mycobacterium smegmatis, Mycobacterium bovis, and Mycobacterium avium, with MIC values indicating strong inhibitory effects. It also shows antimycobacterial activity with effective concentrations (such as IC50 and IC90) in the nanomolar range.
Amikacin affects bacterial growth mechanisms, including binding dissociation constants, bacterial killing efficiencies, and inhibition of biofilm formation and FtsZ ring assembly. Additionally, it has shown a high selectivity ratio favoring bacterial translation inhibition over eukaryotic translation, highlighting its potential as an effective antibacterial agent with reduced cytotoxicity towards human cells.
Overall, Amikacin demonstrates promising bioactivity for further exploration in antimicrobial research and drug development, particularly for its effectiveness against drug-resistant bacterial strains and its potential use in treating a variety of bacterial infections..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin. |
| Synonyms | Amikacinum, Amikacine, Amikacina |
| Molecular Weight | 585.6 |
| Formula | C22H43N5O13 |
| Cas No. | 37517-28-5 |
| Smiles | NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O |
| Relative Density. | 1.6 g/cm3 |
| Storage | store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (85.38 mM), Sonication is recommended. DMSO: 45 mg/mL (76.84 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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