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Isorhamnetin 3-O-galactoside

Catalog No. TN1793   CAS 6743-92-6
Synonyms: Cacticin

Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases.

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Isorhamnetin 3-O-galactoside Chemical Structure
Isorhamnetin 3-O-galactoside, CAS 6743-92-6
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases.
In vitro The anticoagulant activities were investigated by measuring activated partial thromboplastin time (aPTT) and prothrombin time (PT), and the ability to inhibit production of thrombin and activated factor X (FXa) was investigated in human umbilical vein endothelial cells (HUVECs). And, the effects of the compounds on expression of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-(TNF)-α± activated HUVECs. Treatment with IMG and hyperoside resulted in significantly prolonged aPTT and PT and inhibition of the activities of thrombin and FXa, and IMG or hyperoside inhibited production of thrombin and FXa in HUVECs. In accordance with these anticoagulant activities, both agents elicited anticoagulant effects in mouse. In addition, treatment with IMG and hyperoside resulted in inhibition of TNF-α±-induced production of PAI-1, and treatment with IMG resulted in significant reduction of the PAI-1 to t-PA ratio.
Source
Synonyms Cacticin
Molecular Weight 478.4
Formula C22H22O12
CAS No. 6743-92-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside.Food Chem Toxicol. 2013 Mar;53:197-204.

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Keywords

Isorhamnetin 3-O-galactoside 6743-92-6 Apoptosis MAPK NF-Κb ERK TNF NF-κB Isorhamnetin 3 O galactoside Cacticin Isorhamnetin 3Ogalactoside inhibitor inhibit

 

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