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DNA Damage/DNA Repair Topoisomerase Indotecan

Indotecan

Catalog No. T15578   CAS 915303-09-2
Synonyms: LMP-400, NSC-724998

Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).

Indotecan, CAS 915303-09-2
Pack Size Availability Price/USD Quantity
1 mg In stock 100.00
5 mg In stock 205.00
10 mg In stock 343.00
25 mg In stock 623.00
50 mg In stock 1031.00
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Purity 97.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
Targets&IC50 P388 : ic50 300nM ,   HCT116 : ic50 1200nM ,   MCF-7 cell lines : ic50 560 nM
Synonyms LMP-400 , NSC-724998
Purity 97.00%
Molecular Weight 478.49
Formula C26H26N2O7
CAS No. 915303-09-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.

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Irinotecan Hydrochloride Aurintricarboxylic acid Levofloxacin hydrochloride Trovafloxacin Pefloxacin Mesylate Dihydrate Teniposide Rebeccamycin Guajadial C

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.