Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
2 mg | In stock | $ 78.00 | |
5 mg | In stock | $ 115.00 | |
10 mg | In stock | $ 177.00 | |
25 mg | In stock | $ 270.00 | |
50 mg | In stock | $ 447.00 | |
100 mg | In stock | $ 659.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 156.00 |
Description | HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity |
In vitro | halofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS[1]. |
Molecular Weight | 504.8 |
Formula | C19H23BrClN3O6 |
CAS No. | 82186-71-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (44.58 mM)
You can also refer to dose conversion for different animals. More
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HALOFUGINONE LACTATE 82186-71-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Stem Cells DNA/RNA Synthesis TGF-beta/Smad HALOFUGINONE Lactate inhibitor inhibit