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DNA Damage/DNA Repair DNA/RNA Synthesis HALOFUGINONE LACTATE

HALOFUGINONE LACTATE

Catalog No. T8785   CAS 82186-71-8

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity

HALOFUGINONE LACTATE, CAS 82186-71-8
Pack Size Availability Price/USD Quantity
2 mg In stock 87.00
5 mg In stock 128.00
10 mg In stock 197.00
25 mg In stock 301.00
50 mg In stock 497.00
100 mg In stock 839.00
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Purity 99.82%
Biological Description
Chemical Properties
Storage & Solubility Information
Description HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity
In vivo
Molecular Weight 504.8
Formula C19H23BrClN3O6
CAS No. 82186-71-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. 2. Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. 2. Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21. 3. Bin, Guo-Hua, Xian-Feng, et al. Halofuginone protects HUVECs from H2O2-induced injury by modulating VEGF/JNK signaling pathway.[J]. Journal of the Chinese Medical Association : JCMA, 2019.

Related Products

Related compounds with same targets
BMS986260 HALOFUGINONE LACTATE LSKL, Inhibitor of Thrombospondin TSP-1 2,4-Dichlorophenoxyacetic acid NSAH 5-Fluoroorotic acid JH-RE-06 DTP3 TFA (1809784-29-9 free base)

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