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Glucoraphanin

Catalog No. TQ0212 CAS 21414-41-5

Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.

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Glucoraphanin, CAS 21414-41-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 117.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 413.00
50 mg	Inquiry	$ 663.00

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Purity: 99.14%

Purity: 98.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
In vivo	Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improve insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2?/? Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2?/? mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in the liver and adipose tissue [1]. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice [2].
Animal Research	Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2?/?) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food [1].
Source	Natural Products > Brassicaceae > Raphanus

Molecular Weight	437.51
Formula	C12H23NO10S3
CAS No.	21414-41-5

Storage

store at low temperature,store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 74 mg/mL(169.14 mM)

References and Literature

1. Nagata N, et al. Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Diabetes. 2017 May;66(5):1222-1236. 2. Yao W, et al. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Sci Rep. 2016 Jul 29;6:30659.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Obesity Compound Library Kinase Inhibitor Library Selected Plant-Sourced Compound Library Bioactive Compounds Library Max Pyroptosis Compound Library Anti-Liver Cancer Compound Library Anti-Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Glucoraphanin 21414-41-5 Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Reactive Oxygen Species Antioxidant Inhibitor inhibit inhibitor

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